Figure 8.

SP1 overexpression reverses the pro-apoptotic effect of cannabidiol in vivo. A. The tumors of four groups were isolated and compared. B. Tumor growth curve of Sham group, Cannabidiol + Lv-OE-SP1 group, Cannabidiol + Lv-OE-NC group and Cannabidiol group (n=4 per group). Tumor volume was measured every few days. C. Tumor weight was measured at the end of the experiment. D-G. The protein levels of BAX, Bcl2, cleaved caspase-3 and CBX2 in the Sham group, Cannabidiol group, Cannabidiol + Lv-OE-SP1 group, and Cannabidiol + Lv-OE-NC group. The data shown are mean ± SD. **P<0.01 vs. Sham; #P<0.05, ##P<0.01 vs. Cannabidiol + Lv-OE-NC.