TABLE 2.
Broth dilution MICs (μg/ml) for 51 non-L. pneumophila Legionella spp. strainsa
Strain | No. of strains | HMR 3647 | HMR 3004 | Erythro-mycin | Clarithro-mycin | Levo-floxacin |
---|---|---|---|---|---|---|
L. adelaidensis | 1 | 0.004 | 0.004 | 0.125 | 0.012 | 0.008 |
L. anisa | 1 | 0.063 | 0.032 | 0.500 | 0.032 | 0.032 |
L. birminghamiensis | 1 | 0.125 | 0.063 | 0.500 | 0.125 | 0.032 |
L. bozemanii | 4 | 0.059 | 0.030 | 0.256 | 0.024 | 0.023 |
L. brunensis | 1 | 0.063 | 0.012 | 0.500 | 0.064 | 0.032 |
L. cherrii | 1 | 0.032 | 0.032 | 0.250 | 0.032 | 0.016 |
L. cincinnatiensis | 1 | 0.016 | 0.008 | 0.125 | 0.032 | 0.016 |
L. dumofii | 3 | 0.125 | 0.063 | 0.143 | 0.025 | 0.025 |
L. erythra | 1 | 0.250 | 0.125 | 0.750 | 0.125 | 0.016 |
L. fairfieldensis | 1 | 0.004 | 0.004 | 0.032 | 0.012 | 0.125 |
L. feeleii | 3 | 0.016 | 0.008 | 0.315 | 0.050 | 0.040 |
L. geestiana | 1 | 0.063 | 0.032 | 0.250 | 0.064 | 0.004 |
L. gormanii | 2 | 0.061 | 0.061 | 0.217 | 0.039 | 0.023 |
L. gratiana | 1 | 0.063 | 0.032 | 0.500 | 0.032 | 0.064 |
L. hackeliae | 1 | 0.063 | 0.008 | 0.500 | 0.060 | 0.125 |
L. israelensis | 1 | 0.047 | 0.016 | 0.500 | 0.032 | 0.016 |
L. jamestowniensis | 1 | 0.047 | 0.016 | 1.000 | 0.125 | 0.032 |
L. jordanis | 1 | 0.250 | 0.032 | 1.000 | 0.125 | 0.032 |
L. lansingensis | 1 | 0.032 | 0.004 | 0.375 | 0.048 | 0.125 |
L. londiniensis | 1 | 0.032 | 0.016 | 0.188 | 0.032 | 0.008 |
L. longbeachae | 4 | 0.165 | 0.116 | 0.297 | 0.087 | 0.027 |
L. maceachernii | 1 | 0.063 | 0.024 | 0.500 | 0.060 | 0.016 |
L. micdadei | 4 | 0.105 | 0.039 | 0.553 | 0.053 | 0.018 |
L. moravica | 1 | 0.063 | 0.032 | 0.188 | 0.032 | 0.008 |
L. nautarum | 1 | 0.008 | 0.004 | 0.125 | 0.032 | 0.064 |
L. oakridgensis | 1 | 0.063 | 0.008 | 1.000 | 0.060 | 0.016 |
L. quateirensis | 1 | 0.016 | 0.004 | 0.064 | 0.016 | 0.008 |
L. quinlivanii | 1 | 0.063 | 0.024 | 0.188 | 0.032 | 0.032 |
L. rubrilucens | 1 | 0.125 | 0.032 | 0.500 | 0.060 | 0.016 |
L. sainthelensi | 1 | 0.125 | 0.125 | 0.250 | 0.046 | 0.032 |
L. santicrucis | 1 | 0.008 | 0.008 | 0.250 | 0.046 | 0.012 |
L. shakespearei | 1 | 0.063 | 0.032 | 1.000 | 0.064 | 0.125 |
L. spiritensis | 1 | 0.063 | 0.012 | 0.250 | 0.032 | 0.016 |
L. steigerwaltii | 1 | 0.016 | 0.008 | 0.375 | 0.016 | 0.024 |
L. tucsonensis | 1 | 0.008 | 0.004 | 0.064 | 0.006 | 0.032 |
L. wadsworthii | 1 | 0.032 | 0.008 | 0.250 | 0.032 | 0.008 |
L. worsleiensis | 1 | 0.008 | 0.004 | 0.032 | 0.006 | 0.006 |
Overall mean | 0.053 | 0.023 | 0.291 | 0.040 | 0.024 | |
MIC50b | 0.062 | 0.032 | 0.50 | 0.032 | 0.032 | |
MIC90c | 0.125 | 0.062 | 0.500 | 0.125 | 0.064 | |
Minimum | 0.004 | 0.004 | 0.032 | 0.004 | 0.004 | |
Maximum | 0.250 | 0.125 | 1.0 | 0.125 | 0.125 |
All values represent geometric means of duplicate determinations; geometric means are also used to calculate mean values for results of multiple strains of a single species.
MIC50, MIC at which 50% of the strains are inhibited.
MIC90, MIC at which 90% of the strains are inhibited.