Figure 1.

Diagnostic performance of published clinical prediction rules versus the RISK11 transcriptomic signature

Receiver operating characteristic (ROC) curves comparing diagnostic performance (area under the curve, AUC, with 95% CI) for prevalent TB diagnosed on one or more liquid culture-positive or Xpert MTB/RIF-positive sputum samples of (a) the RISK11 transcriptomic signature versus the Hanifa2017 and Baik2020 clinical prediction scores, and (b) the RISK11 transcriptomic signature versus the Periskope-TB tool (intended for prognosis in low TB incidence settings) and interferon-γ release assay (IGRA). The shaded areas represent the 95% CIs. The solid box depicts the optimal criteria (95% sensitivity and 80% specificity) and the dashed box depicts the minimal criteria (90% sensitivity and 70% specificity) set out in the WHO Target Product Profile for a TB triage test.²⁸