Table C.1.

Potential sources of uncertainty identified in the assessment of potential microbiological food safety concerns in HPP‐treated food

Source or location of the uncertainty	Nature or cause of the uncertainty	Impact of the uncertainty on the conclusions (e.g. over/underestimation)
Incompleteness in the identification of potential microbiological food safety concerns	It is possible that the final list of potential food safety concerns is not complete. The list was populated relying on the available scientific literature as well as the expert knowledge.	The impact of this uncertainty is expected to be low as it is believed that all potential microbiological food safety concerns have been identified from the current available evidence. In case a potential concern would have been omitted, the concern for human health may have been underestimated.
Exclusivity of the identified microbial food safety concerns to HPP and the lack of evidence in the assessment of (an) identified potential microbiological food safety concern(s)	It is possible that the identified food safety concerns, which have been considered common to other thermal and novel inactivation technologies, is exclusive to HPP. Additionally, if could be possible that a potential safety concern has been identified but there is a lack of evidence in the literature for the identified specific microbiological safety concerns.	The impact of this uncertainty is expected to be low because none of the identified safety concerns have been exclusive for the HPP treatment, so the lack of evidence will not impact the final assessment.

HPP: high‐pressure processing.