Table 5.
Summary of mental and physical health changes (measured by the Patient-Reported Outcomes Measurement Information System) across the 2-month follow-up in patients who presented to an orthopedic clinic for a musculoskeletal condition and reported coexisting symptoms of depression and anxiety subgrouped by frequency of use of a digital mental health intervention (Wysa).
| PROMISa domain | Baseline (n=61), mean (95% CI) | 2-month follow-up (n=51)b, mean (95% CI) | Within-group longitudinal change, mean (95% CI) | Between-group changec |
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Mean (95% CI) | P value | |
| Depression | −3.2 (−7.5 to 1.2) | .15 | ||||
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High usersd | 57.5 (54.5 to 60.4) | 52.8 (49.9 to 55.8) | −4.7 (−7.5 to −1.8) |
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Low userse | 58.7 (55.8 to 61.7) | 57.3 (53.9 to 60.7) | −1.5 (−4.7 to 1.8) |
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| Anxiety | −4.2 (−8.1 to −0.2) | .04 | ||||
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High users | 62.1 (59.6 to 64.7) | 56.6 (54.0 to 59.1) | −5.6 (−8.2 to −3.0) |
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Low users | 62.4 (59.8 to 64.9) | 61.0 (58.0 to 63.9) | −1.4 (−4.4 to 1.6) |
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| Pain interference | −2.3 (−6.3 to 1.7) | .26 | ||||
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High users | 64.5 (62.1 to 66.8) | 60.6 (58.2 to 63.0) | −3.9 (−6.5 to −1.2) |
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Low users | 65.9 (63.5 to 68.3) | 64.3 (61.6 to 67.1) | −1.5 (−4.6 to 1.5) |
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| Physical function | 0.0 (−3.4 to 3.5) | .99 | ||||
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High users | 37.1 (34.6 to 39.5) | 40.5 (38.0 to 42.9) | 3.4 (1.2 to 5.7) |
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Low users | 34.7 (32.3 to 37.1) | 38.0 (35.3 to 40.8) | 3.4 (0.8 to 6.0) |
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aPROMIS: Patient-Reported Outcomes Measurement Information System.
bThe 2-month follow-up PROMIS measures were available for 30 high and 21 low Wysa users.
cClinically meaningful effect sizes are defined as at least 3.2 points for PROMIS Depression, 3.0 points for Anxiety, 2.0 points for Pain Interference, and 2.2 points for Physical Function [34-36].
dThere were 30 patients in the high Wysa use subgroup.
eThere were 31 patients in the low Wysa use subgroup.