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. 2022 Feb 17;10:839062. doi: 10.3389/fchem.2022.839062

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Copyright © 2022 Yan, Li, Wu, Zhang, Hu, Deng, Jiang, Wen and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quality and quantity of regenerated bone tissue on Sr-Zn-augmented titanium surfaces in the OVX rat model. (A) The scheme of animal operation: the 12-week-old rat femoral model was constructed by ovariectomy, and at 20 weeks old, the implant surgery was conducted. At 2 and 6 weeks after implant surgery, the fluorescent labeling was injected. The bone tissue and samples were harvested at 28 weeks old. (B-E) Reconstructed 3D models of surrounding bones in micro-CT with inserted implants of longitudinal section with (B) or without implant (C) and of transverse section with (D) or without implant (E). Quantitative analysis includes (F) BV/TV and (G) Tb. Th. (H) Peak load of the samples compared with the TiO₂ group.