Table 2. Changes in Cerebral Blood Flow by Treatment Group.
| Outcome | Cerebral blood flow, (95% CI), mL/100 g/mina | Difference in change (95% CI) | P value | |||||
|---|---|---|---|---|---|---|---|---|
| Intensive treatment | Standard treatment | |||||||
| Baseline | Follow-up | Change | Baseline | Follow-up | Change | |||
| Whole brain | 38.90 (36.64 to 41.17) | 40.36 (37.95 to 42.77) | 1.46 (0.08 to 2.83) | 37.96 (35.67 to 40.26) | 37.12 (34.66 to 39.58) | –0.84 (–2.30 to 0.61) | 2.30 (0.30 to 4.30) | .02 |
| Gray matter | 50.76 (47.01 to 54.52) | 52.91 (49.01 to 56.80) | 2.14 (0.41 to 3.87) | 49.40 (45.61 to 53.19) | 49.06 (45.11 to 53.00) | –0.34 (–2.17 to 1.48) | 2.49 (–0.03 to 5.00) | .05 |
| White matter | 19.86 (18.85 to 20.88) | 20.51 (19.35 to 21.67) | 0.65 (–0.32 to 1.61) | 19.41 (18.36 to 20.46) | 18.57 (17.36 to 19.79) | –0.83 (–1.85 to 0.18) | 1.48 (0.08 to 2.88) | .04 |
| Periventricular white matter | 15.79 (14.81 to 16.78) | 16.11 (15.01 to 17.21) | 0.32 (–0.54 to 1.17) | 15.48 (14.47 to 16.50) | 14.60 (13.45 to 15.76) | –0.88 (–1.80 to 0.04) | 1.20 (–0.06 to 2.45) | .06 |
a
Estimates based on a linear mixed model, adjusting for age, sex, and days since randomization, with random effects for participant and magnetic resonance imaging facility. Estimates represent least-square means, with follow-up estimates computed at 1452 days (4.0 years) postrandomization, which was the median follow-up in both treatment groups. For change estimates, negative values denote decreases from baseline, while positive values indicate increases from baseline. Difference in change represents intensive treatment group minus standard treatment.