TABLE 1.
Pharmacokinetic parameters of DA-1131 after a 1-min i.v. infusion of the drug at 100 mg/kg to rabbits with (treatment I) or without (treatment II) the administration of probenecid at 50 mg/kga
| Parameter | Treatment I (n = 6) | Treatment II (n = 9) |
|---|---|---|
| t1/2 (min) | 20.1 ± 7.65 | 17.2 ± 5.19 |
| AUC (μg · min/ml)b | 13,900 ± 1,510 | 7,980 ± 2,000 |
| AUMC (μg · min2/ml)b | 391,000 ± 92,500 | 118,000 ± 47,300 |
| MRT (min)b | 27.9 ± 4.01 | 14.4 ± 3.79 |
| CL (ml/min/kg)c | 7.21 ± 0.782 | 12.5 ± 4.29 |
| CLR (ml/min/kg)c | 3.87 ± 0.543 | 6.14 ± 2.09 |
| CLNR(ml/min/kg)c | 3.10 ± 0.911 | 5.86 ± 2.85 |
| CLCR (ml/min/kg)c | 3.54 ± 1.23 | 2.26 ± 0.589 |
| VSS (ml/kg) | 200 ± 21.7 | 176 ± 47.5 |
| XU 0–8 (% of i.v. dose) | 54.8 ± 9.28 | 50.3 ± 9.80 |
a
Values are means ± standard deviations.
b
P < 0.001.
c
P < 0.05.