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. 2022 Feb 22;13:835830. doi: 10.3389/fimmu.2022.835830

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Copyright © 2022 Taus, Hofmann, Ibarrondo, Hausner, Fulcher, Krogstad, Ferbas, Tobin, Rimoin, Aldrovandi and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spike targeting after vaccination of persons without prior SARS-CoV-2 infection is broadly distributed. 22 persons without a history of SARS-CoV-2 infection were monitored for responses against spike and nucleocapsid (negative control) by ELISpot assay after vaccination with BNT162b2 (15 persons) or mRNA-1273 (7 persons). Responses were evaluated a mean of 11.3 days after the first vaccine dose (range 8 to 16 days). (A) Frequencies of responses against each pool are plotted for each participant. The mean total response against spike was 2,463 SFC/million CD8⁺ T cells. (B) Percentages of persons responding against each pool are plotted. Targeting of spike was an average of 4.2 pools per person. Response against pools S4 and S5, comprising the receptor binding domain of spike, was an average 1.0 peptide pools per person.