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BGB-A1217 elicits strong immune responses and potent anti-tumor efficacy through multiple mechanisms of action. (A) Rejuvenation of T and NK cells. (B) Preferential Treg depletion through ADCC/ADCP. (C) NK activation through TIGIT binding and FcγR crosslinking. (D) Myeloid cell activation through FcγR crosslinking. (E) Removal of TIGIT molecules from T cell and NK cell surfaces.
