Table 4.
Baseline (n = 59) | On LT4 (n = 49) | On LT3 (n = 48) | LT4 vs. LT3 (n = 47) | ||||
---|---|---|---|---|---|---|---|
Score | Change from baseline | P value | Change from baseline | P value | Change from LT4 to LT3 | P value | |
Goiter symptoms | 19 ± 18 | 1 ± 17 | 0.730 | -5 ± 12 | 0.014 | -6 ± 14 | 0.030 |
Hyperthyroid symptoms | 24 ± 15 | -1 ± 13 | 0.493 | -5 ± 13 | 0.008 | -4 ± 14 | 0.081 |
Hypothyroid symptoms | 49 ± 20 | -2 ± 19 | 0.417 | -12 ± 19 | <0.001 | -9 ± 19 | 0.002 |
Eye symptoms | 30 ± 20 | -3 ± 16 | 0.202 | -8 ± 15 | 0.001 | -4 ± 16 | 0.073 |
Tiredness | 71 ± 16 | -4 ± 19 | 0.110 | -21 ± 26 | <0.001 | -15 ± 27 | <0.001 |
Cognitive complaints | 51 ± 26 | -9 ± 20 | 0.003 | -20 ± 20 | <0.001 | -9 ± 22 | 0.006 |
Anxiety | 31 ± 25 | 1 ± 19 | 0.636 | -9 ± 24 | 0.008 | -8 ± 18 | 0.004 |
Depressivity | 39 ± 21 | 0 ± 19 | 0.968 | -10 ± 21 | 0.003 | -9 ± 18 | 0.001 |
Emotional susceptibility | 42 ± 22 | 0 ± 21 | 0.881 | -9 ± 24 | 0.018 | -8 ± 19 | 0.004 |
Impaired social life | 32 ± 21 | -3 ± 19 | 0.343 | -10 ± 21 | 0.002 | -7 ± 18 | 0.015 |
Impaired daily life | 37 ± 23 | -9 ± 18 | 0.001 | -16 ± 23 | <0.001 | -7 ± 22 | 0.041 |
Cosmetic complaints | 30 ± 23 | 7 ± 19 | 0.022 | -3 ± 20 | 0.275 | -9 ± 16 | <0.001 |
Overall QoL | 57 ± 25 | -1 ± 27 | 0.892 | -11 ± 29 | 0.017 | -9 ± 28 | 0.041 |
Data are presented as mean ± SD. Each scale in ThyPRO is scored between 0-100, where higher scores indicating worse QOL.