Table 3.
Performance of Spike SNP assays in saliva.
| Whole Genome Sequencing Result | Assay Clinical Analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Screening Assay Result | Reference | Substitution | Alternate | % Accuracy | % Clinical Sensitivity | % Clinical Specificity | % PPV | % NPV | |
| K417T | Reference | 176 | 0 | 0 | 99.20 | 100.0 | 98.87 | 97.29 | 100.0 |
| Substitution | 0 | 64 | 0 | ||||||
| Inconclusive | 2 | 0 | 8 | ||||||
|
| |||||||||
|
| |||||||||
| E484K | Reference | 173 | 0 | 0 | 96.40 | 100.0 | 95.05 | 88.31 | 100.0 |
| Substitution | 0 | 68 | 68 | ||||||
| Inconclusive | 2 | 7 | 0 | ||||||
|
| |||||||||
|
| |||||||||
| E484Q | Reference | 179 | 0 | 0 | 99.60 | 100.0 | 99.44 | 98.59 | 100.0 |
| Substitution | 0 | 0 | 0 | ||||||
| Inconclusive | 1 | 0 | 70 | ||||||
|
| |||||||||
|
| |||||||||
| L452R | Reference | 181 | 2 | 0 | 96.80 | 96.82 | 96.79 | 91.04 | 98.90 |
| Substitution | 0 | 61 | 0 | ||||||
| Inconclusive | 4 | 2 | 0 | ||||||