TABLE 1.
CHARACTERISTICS OF THE STUDY COHORTS
| Adult cohorts (n=280) | Chile MIS-C cohort (n=27) | ||
|---|---|---|---|
| Age: 60 (19–92) | Age: 6 (3–11) | ||
| Feature | Number (%) | Feature | Number (%) |
| Male | 192 (68.6) | Male | 16 (59) |
| Disease severity | Disease severity | ||
| Critical | 168 (60) | Moderate MIS-C | 12 (44) |
| Severe | 41 (16.1) | Severe MIS-C | 15 (56) |
| Moderate | 38 (13.6) | ICU Admission | 23 (85) |
| Mild/Asymptomatic | 24 (8.6) | Pneumonia | 4 (14) |
| Site | Oxygen Supplementation | ||
| Brescia | 236 (84.3) | Invasive mechanical | 12 (44) |
| Monza | 25 (8.9) | Non-invasive mechanical | 0 (0) |
| ICU | 77 (27.5) | Face mask with reservoir | 0 (0) |
| Pneumonia | 230 (85) | Low flow oxygen | 2 (8) |
| Oxygen Supplementation | No oxygen | 13 (48) | |
| Invasive mechanical | 61 (21.8) | ||
| Non-invasive mechanical | 57 (20.4) | Italian MIS-C cohort (n=6) | |
| Face mask with reservoir | 16 (5.7) | Age: 5.8 (0.3–12) | |
| Low flow oxygen | 40 (14.3) | Feature | Number (%) |
| No oxygen | 16 (5.7) | Male | 3 (50) |
| Unrecorded | 71 (25.4) | MIS-C | 6 (100) |
| Deceased | 45 (16.1) | Site | |
| Turin | 3 (50) | ||
| Italian CLL cohort (n=17) | Naples | 3 (50) | |
| Age: 13 (9–15) | ICU | 1 (16.7) | |
| Feature | Number (%) | Pneumonia | 3 (50) |
| Male | 9 (52.9) | ||
| COVID toes | 17 (100) | USA CLL cohort (n=9) | |
| Naples | 17 (100) | Age: 17 (14–19.5) | |
| Hospitalization Status | Feature | Number (%) | |
| Non-ICU | 1 (5.9) | Male | 5 (55.5) |
| Not hospitalized | 16 (94.1) | Family history of autoimmunity | 1 (11.1) |
| Recurrence(s) | 3 (33.3) | ||
| Adult Omicron cohort (n=21) | Systemic symptoms | 0 (0) | |
| Age: 73 (64–85) | Median (IQR) | ||
| Feature | Number (%) | Duration of skin symptoms (d) | 145 (79) |
| Omicron | 21 (100) | ||
| Vaccinated | 0 (0.0) | ||
| Male | 13 (61.9) | ||
| Hypertension | 6 (28.5) | ||
| ICU | 3 (14.2) | ||
| Pneumonia | 17 (80.9) | ||
| Critical | 16 (76.1) | ||
IQR: interquartile range; ICU: intensive care unit.