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Time-kill curve of C. albicans by three bicyclic guanidines. The mean log10 CFU per milliliter are plotted versus incubation time for C. albicans tested against the bicyclic guanidines. ■, R1 = 1-adamantaneacetic acid, R2 = l-cyclohexylalanine, R3 = d-cyclohexylglycine; ⧫, R1 = 4-t-butyl-cyclohexanecarboxylic acid, R2 = l-cyclohexylalanine, R3 = d-cyclohexylalanine; ▴, R1 = 1-adamantaneacetic acid, R2 = d-cyclohexylalanine, R3 = d-cyclohexylglycine; ✶, control without test compounds.
