TABLE 2.
Activities of the most active mixtures of the bicyclic guanidine PS-SCL against C. albicans
| Building block | IC50 (μg/ml) | MIC (μg/ml) |
|---|---|---|
| R1 defined | ||
| 4-t-Butyl-cyclohexanecarboxylic acid | 19 ± 1.3 | 32–62 |
| 1-Adamantaneacetic acid | 22 ± 7.8 | 32–62 |
| Cyclohexylbutyric acid | 40 ± 0.8 | 50–62 |
| 2-Norbornaneacetic acid | 54 ± 10 | 125–250 |
| Heptanoic acid | 80 ± 3.3 | 125–250 |
| 3-Cyclopentylpropionic acid | 80 ± 6.5 | 125–250 |
| 4-Methyl-cyclohexanecarboxylic acid | 82 ± 2.4 | 125–250 |
| Cyclohexylacetic acid | 85 ± 17 | 125–250 |
| 3-Methylvaleric acid | 119 ± 38 | >250 |
| R2 defined | ||
| l-Cyclohexylalanine | 20 ± 1.1 | 32–62 |
| d-Cyclohexylalanine | 23 ± 5.9 | 32–62 |
| l-Cyclohexylglycine | 48 ± 8.5 | 70–125 |
| d-Cyclohexylglycine | 78 ± 1.8 | 125–250 |
| d-Isoleucine | 80 ± 1.1 | 125–250 |
| d-p-Chlorophenylalanine | 88 ± 23 | >250 |
| Glycine | 138 ± 4.7 | 150–250 |
| d-Leucine | 169 ± 0.6 | >250 |
| R3 defined | ||
| l-Cyclohexylalanine | 18 ± 1.2 | 20–32 |
| d-Cyclohexylalanine | 19 ± 0.6 | 25–32 |
| d-Cyclohexylglycine | 34 ± 1.1 | 40–62 |
| l-Cyclohexylglycine | 37 ± 4.8 | 45–62 |
| l-p-Fluorophenylalanine | 94 ± 15 | >250 |
| d-p-Fluorophenylalanine | 97 ± 16 | 125–250 |
| d-Norleucine | 105 ± 23 | >250 |
| l-ɛ-Acetyl-lysine | 145 ± 22 | >250 |