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IL-38 protective effects and its consequence in mice poly(I:C) induced lung inflammation [39]
| Target | The effects | Consequence |
|---|---|---|
| CD4 + CD25 + Foxp3 + splenic Treg cells | Upregulation | Improving severe acute lung injury |
| Rising blood oxygen level | ||
| Myeloid and lymphoid cells | Mitigate their numbers and the production of IL-17, CXCL-1, CXCL-10, CCL-2, and CCL-5 | Improving lung inflammation |
| Neutrophils | Reduce their number leading to downregulation of IL-1β, TNF-α, and IL-6 | Alleviate cytokine storm |
