TABLE 2.
Radioactively labeled antibiotic concentration in vegetation per injected radioactivity and vegetation/plasma, vegetation/blood, and vegetation/cardiac tissue ratio of [14C]LY333328 concentrations according to time of sampling
| Time of sacrifice after antibiotic infusion | Dose injected (μCi) ± SD (no. of animals) | No. of vegetations | Radioactivity in vegetation/injected radioactivity ± SDa | Ratio of mean antibiotic radioactivity ± SDb
|
||
|---|---|---|---|---|---|---|
| Vegetation/plasma | Vegetation/blood | Vegetation/cardiac tissue | ||||
| 30 min | 235 ± 165 (2) | 8 | 1,108 ± 918 | 0.42 ± 0.24 | 1.20 ± 0.67 | 2.21 ± 1.79 |
| 12 h | 457 (1) | 4 | 1,639 ± 450 | 1.61 ± 0.44c | 4.36 ± 1.20c | 6.30 ± 1.73c |
a
Disintegrations per minute per gram/disintegrations per minute, 10−6.
b
The vegetation/plasma and vegetation/blood ratios are expressed as disintegrations per gram/disintegrations per milliliter, and the vegetation/cardiac tissue ratio is expressed as disintegrations per gram/disintegrations per gram.
c
P < 0.01 versus vegetations from animals sacrificed 30 min after antibiotic infusion.