Table 1.

Demographics of subcohort (N = 675)

N	N= 675
Baseline NT-proBNP, median (IQR) (pg/mL)	96 (37-216)
Absolute change in NT-proBNP, median (IQR) (pg/mL)	50 (−12 – 191)
Relative change in NT-proBNP, median (IQR) (%)	85 (−10 – 330)
Baseline hsTNT, median (IQR) (ng/mL)	12.4 (7.9-19.8)
Absolute change in hsTNT, median (IQR) (ng/mL)	2.8 (−0.2 – 9.4)
Relative change in hsTNT, median (IQR) (%)	23 (−2 – 70)
Baseline GDF-15, median (IQR) (pg/mL)	1318 (906-1874)
Absolute change in GDF-15, median (IQR) (pg/mL)	110 (−96 – 524)
Relative change in GDF-15, median (IQR) (%)	11 (−9 – 41)
Baseline Galectin-3, median (IQR) (ng/mL)	13.5 (9.7-17.9)
Absolute change in Galectin-3, median (IQR) (ng/mL)	2.8 (−0.5 – 6.4)
Relative change in Galectin-3, median (IQR) (%)	22 (−4 – 52)
Baseline sST-2, median (IQR) (ng/mL)	14.7 (10.5-20.1)
Absolute change in sST-2, median (IQR) (ng/mL)	−0.5 (−3.7 – 3.3)
Relative change in sST-2, median (IQR) (%)	−4 (−24 – 27)
Age (years)	59.4 (11.2)
Women	310 (44)
Race/ethnicity
Non-Hispanic white	332 (47)
Non-Hispanic black	249 (36)
Hispanic	86 (12)
Other	33 (5)
Baseline eGFR (CKD-EPI), mL/min/1.73m2	46.8 (14.1)
Relative change (%) in eGFR (CKD-EPI)	−8.2 (20.9)
24-hour urine protein (g/d), median	0.1 (0.1-0.5)
Diabetes	302 (43)
History of CVD
Never	522 (75)
At Year 2 only	21 (3)
At baseline and Year 2	157 (22)
Current smoker	70 (10)
BMI (kg/m2)	31.5 (7.4)
SBP (mmHg)	125.1 (20.4)
DBP (mmHg)	69.9 (12.4)
LDL cholesterol (mg/dL)	100.7 (33.6)
HDL cholesterol (mg/dL)	48.1 (15.5)
ACEi/ARBs
Never	160 (23)
At Year 2 only	64 (9)
At baseline and Year 2	426 (61)
Diuretics
Never	262 (37)
At Year 2 only	62 (9)
At baseline and Year 2	297 (42)
Beta blockers
Never	358 (51)
At Year 2 only	62 (9)
At baseline and Year 2	239 (34)
PTH, median	46.5 (31.0-76.0)