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. Author manuscript; available in PMC: 2022 Mar 8.
Published in final edited form as: Ageing Res Rev. 2021 Oct 9;72:101485. doi: 10.1016/j.arr.2021.101485

Figure 2. Balanced effects of different sized HA polymers.

Figure 2.

While LMW-HA activates pro-inflammatory and proliferative signaling cascades effects via TLR2/4 and CD44, HMW-HA has anti-hyperalgesic, anti-proliferative and anti-apoptotic activities, potentially by causing a different conformation of its major receptor, CD44. vHMW-HA, additionally, has superior cytoprotective properties. Both LMW-HA and HMW-HA are important for wound healing and tissue maintenance. Disparity of differentially sized HA effects happens on receptor level.