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. 2022 Feb 22;19(2):e1003933. doi: 10.1371/journal.pmed.1003933

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© 2022 Yang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) M–L phylogeny of 1,834 Moldova M. tuberculosis isolates based on 43,284 variable sites. The outer bands represent the in silico drug-resistant profiles, treatment history of participant and the region where the isolates were sampled from. The tree is rooted to Mycobacterium bovis (branch in green). L2 denotes lineage 2 (light orange) and L4 lineage 4 (light blue). Three major clades from the Ural/ lineage 4.2.1 (clade 1) and Beijing/lineage2.2.1 (clades 2 to 3) are shaded. The main nodes of the tree have 100% bootstrap support. (B) Phylogenetic distribution of resistance-related genotypes. The columns depict loci associated with drug resistance. “P” followed by a subscription of gene name indicates the promotor region. Colored bands of each column represent different polymorphisms. DR, drug resistance; MDR, multidrug resistance; MDR-TB, multidrug-resistant tuberculosis; M–L, maximum–likelihood.