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. 2022 Feb 22;19(2):e1003933. doi: 10.1371/journal.pmed.1003933

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© 2022 Yang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A–C) Coalescent Bayesian Skyline plots of the 3 large clades among Ural/lineage 4.2.1 and Beijing/lineage 2.2.1 with specific resistant mutations (detailed in Fig 2B) using an uncorrelated log normal relaxed clock model. The 2 blue lines are the upper and lower bounds of the 95% HPD interval. The x-axis is the time in years and the y-axis is on a log scale. (D) Density distribution of within-clade pairwise SNPs distance of clades 1 to 3. HPD, highest posterior density; SNP, single nucleotide polymorphism.