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. 2022 Mar 8;17(3):e0264123. doi: 10.1371/journal.pone.0264123

Table 4. Epidemiological data on study population.

Variable Value Source
Italian Population 59,641,488 21
Multiple sclerosis (MS) prevalence rate 0.2% 22
Number of prevalent MS patients in the model 119,283 Estimated
SPMS prevalence 13.7% 18, 23 and expert opinion
Number of subjects with SPMS 16,342 Estimated
Percentage of patients with SPMS age 18–60 and EDSS between 3–6.5 91.8% 18, 23 and expert opinion
Number of patients with SPMS age 18–60 and EDSS between 3–6.5 15,001 Estimated
Percentage of patients with active SPMS 60.0% 23
Number of patients with active SPMS 9,002 Estimated
Percentage of patients with active SPMS and under-treatment 65.0% 21
Number of patients with active SPMS and under-treatment 5,851 Estimated
Percentage of patients eligible for siponimod treatment 99.6% 24
Number of patients eligible for siponimod treatment 5,827 Estimated