TABLE 3.

R², bias, and precision of the best linear equations for n sample times derived by using the all-subset regression approach to estimate the AUC_0–∞ for each of the 18 subjects for the four preparation-compund pairs tested

Preparation-compound	n	Sample time(s) (h)	R2	MD (% [mean ± SD])	MAD (% [mean ± SD])
SPOR-ITR	1	48	97.32	−5.88 ± 23.34	14,99 ± 18.53
	2	4, 48	99.06	−2.23 ± 12.85	7.99 ± 10.13
	3	1, 4, 48	99.50	−2.23 ± 13.24	7.05 ± 11.31
	4	1, 2, 4, 48	99.69	−1.50 ± 11.39	6.34 ± 9.46
	5	1, 2, 4, 10, 48	99.85	−0.61 ± 5.69	3.98 ± 4.00
	6	1, 2, 3, 4, 8, 48	99.92	−0.34 ± 3.95	2.94 ± 2.57
	7	1, 2, 3, 4, 8, 24, 48	99.95	−0.42 ± 3.73	2.53 ± 2.71
	8	1, 2, 3, 4, 8, 10, 24, 48	99.95	−0.39 ± 3.58	2.36 ± 2.66
	9	1, 2, 3, 4, 5, 6, 8, 24, 48	99.95	−0.38 ± 3.75	2.37 ± 2.88
	10	1, 2, 3, 4, 5, 6, 8, 10, 24, 48	99.95	−0.35 ± 3.61	2.22 ± 2.81
TRAC-ITR	1	24	95.50	−1.55 ± 13.50	10.74 ± 7.91
	2	8, 48	97.62	−1.52 ± 10.09	7.07 ± 7.17
	3	3, 8, 48	99.33	−0.83 ± 5.49	4.15 ± 3.55
	4	1, 2, 5, 48	99.59	−0.15 ± 4.93	3.44 ± 3.44
	5	2, 5, 8, 24, 48	99.74	−0.31 ± 3.67	2.70 ± 2.42
	6	2, 5, 8, 10, 24, 48	99.79	−0.14 ± 3.36	2.48 ± 2.20
	7	1, 2, 5, 8, 10, 24, 48	99.80	−0.07 ± 3.20	2.43 ± 2.00
	8	1, 2, 4, 5, 8, 10, 24, 48	99.80	−0.11 ± 2.99	2.38 ± 1.73
	9	1, 2, 4, 5, 6, 8, 10, 24, 48	99.81	−0.12 ± 2.97	2.37 ± 1.70
	10	1, 2, 3, 4, 5, 6, 8, 10, 24, 48	99.81	−0.12 ± 2.94	2.31 ± 1.73
SPOR-HYD	1	48	96.07	−11.20 ± 43.43	25.78 ± 36.27
	2	8, 48	98.53	−0.51 ± 11.17	8.31 ± 7.21
	3	1, 8, 48	98.68	−0.19 ± 9.25	7.12 ± 5.65
	4	1, 2, 8, 48	98.76	−0.35 ± 10.75	8.15 ± 6.74
	5	1, 4, 5, 8, 48	98.80	0.20 ± 10.58	7.69 ± 7.03
	6	1, 4, 5, 6, 8, 48	98.90	−0.34 ± 11.20	7.94 ± 7.66
	7	1, 3, 5, 6, 8, 24, 48	98.97	−0.81 ± 12.36	9.51 ± 7.60
	8	1, 2, 3, 5, 6, 8, 24, 48	99.03	−0.85 ± 12.01	9.05 ± 7.63
	9	1, 2, 3, 5, 6, 8, 10, 24, 48	99.07	−0.75 ± 11.51	8.33 ± 7.71
	10	1, 2, 3, 4, 5, 6, 8, 10, 24, 48	99.10	−0.48 ± 11.01	7.67 ± 7.69
TRAC-HYD	1	24	96.20	0.76 ± 14.33	11.52 ± 8.10
	2	5, 48	99.22	−0.21 ± 7.30	5.37 ± 4.77
	3	3, 10, 48	99.67	0.06 ± 5.30	3.59 ± 3.79
	4	3, 10, 24, 48	99.81	0.24 ± 2.69	2.14 ± 1.57
	5	2, 4, 10, 24, 48	99.88	0.04 ± 1.74	1.55 ± 0.70
	6	2, 4, 5, 10, 24, 48	99.89	0.12 ± 1.85	1.65 ± 0.75
	7	2, 4, 5, 8, 10, 24, 48	99.90	0.08 ± 2.02	1.69 ± 1.02
	8	1, 2, 4, 5, 6, 10, 24, 48	99.90	0.09 ± 2.09	1.77 ± 1.05
	9	1, 2, 3, 4, 5, 6, 10, 24, 48	99.90	0.11 ± 2.02	1.65 ± 1.10
	10	1, 2, 3, 4, 5, 6, 8, 10, 24, 48	99.90	0.11 ± 2.02	1.65 ± 1.10