TABLE 4.

R², bias, and precision of the ten best linear equations on three sample times derived by the all-subset regression approach to estimate the AUC_0–∞ for each of the 18 subjects for the four preparation-compund pairs tested

Preparation compund	R2	Equation	MD (% [mean ± SD])	MAD (mean % ± SD)
SPOR-ITR	99.50	333.93 − 3.97 · C1 + 4.78 · C4 + 106.28 · C48	−2.23 ± 13.24	7.05 ± 11.31
	99.32	175.23 + 3.13 · C4 + 4.44 · C6 + 100.09 · C48	−1.17 ± 8.03	5.30 ± 6.02
	99.27	247.34 + 3.49 · C4 + 5.00 · C8 + 95.84 · C48	−2.04 ± 8.80	5.33 ± 7.19
	99.27	−74.92 + 2.41 · C2 + 9.72 · C6 + 100.82 · C48	0.39 ± 6.19	5.18 ± 3.16
	99.25	224.80 + 3.69 · C4 + 6.28 · C10 + 93.41 · C48	−1.86 ± 8.40	5.42 ± 6.57
	99.17	156.21 + 2.04 · C3 + 6.49 · C6 + 103.10 · C48	−1.27 ± 7.86	5.56 ± 5.54
	99.16	268.14 + 3.32 · C4 + 1.73 · C5 + 103.08 · C48	−1.87 ± 10.61	6.72 ± 8.27
	99.10	207.41 + 2.70 · C3 + 10.85 · C10 + 90.32 · C48	−2.20 ± 8.67	5.61 ± 6.86
	99.10	55.61 + 2.80 · C2 + 12.86 · C8 + 90.39 · C48	−1.56 ± 6.74	5.24 ± 4.35
	99.09	301.27 + 3.99 · C4 + 5.91 · C24 + 98.20 · C48	−2.20 ± 11.85	7.20 ± 9.51
TRAC-ITR	99.33	117.69 + 2.56 · C3 + 11.16 · C8 + 79.89 · C48	−0.83 ± 5.49	4.15 ± 3.55
	99.14	111.52 + 4.34 · C1 + 6.67 · C5 + 95.52 · C48	−0.13 ± 7.08	4.84 ± 5.02
	98.92	92.87 + 2.59 · C4 + 11.15 · C8 + 77.45 · C48	−0.92 ± 6.51	4.94 ± 4.17
	98.76	148.01 + 1.62 · C2 + 12.23 · C8 + 90.49 · C48	−1.32 ± 7.70	5.05 ± 5.84
	98.72	177.75 + 1.83 · C2 + 42.37 · C24 + 60.99 · C48	−1.30 ± 9.39	6.37 ± 6.86
	98.69	169.68 + 2.53 · C3 + 36.01 · C24 + 59.89 · C48	−1.06 ± 8.68	6.31 ± 5.86
	98.62	107.79 + 1.97 · C2 + 5.56 · C5 + 98.34 · C48	−0.50 ± 5.59	4.66 ± 2.92
	98.50	4.09 + 3.82 · C5 + 10.96 · C8 + 83.21 · C48	−0.44 ± 7.53	5.57 ± 4.89
	98.30	77.04 + 10.04 · C8 + 28.59 · C24 + 61.84 · C48	−1.15 ± 8.54	6.01 ± 6.00
	98.20	75.83 + 2.36 · C2 + 8.10 · C6 + 98.52 · C48	−0.56 ± 6.88	5.38 ± 4.13
SPOR-HYD	98.68	218.84 + 5.58 · C1 + 15.14 · C8 + 98.23 · C48	−0.19 ± 9.25	7.12 ± 5.65
	98.56	274.81 ± 1.07 · C2 + 14.87 · C8 + 99.40 · C48	−0.35 ± 9.99	7.40 ± 6.47
	98.56	321.88 + 3.25 · C5 + 11.20 · C8 + 100.61 · C48	−0.36 ± 11.10	8.35 ± 7.04
	98.55	351.45 ± 1.18 · C4 + 13.75 · C8 + 99.84 · C48	−0.46 ± 10.77	7.93 ± 7.04
	98.54	428.49 + 13.53 · C8 + 4.57 · C24 +94.90 · C48	−0.47 ± 11.43	8.62 ± 7.23
	98.54	342.17 + 0.44 · C3 + 14.95 · C8 + 99.20 · C48	−0.47 ± 10.85	8.08 ± 6.99
	98.53	358.86 + 16.60 · C8 − 1.29 · C10 + 99.15 · C48	−0.57 ± 11.34	8.43 ± 7.33
	98.53	342.01 + 0.51 · C6 + 14.89 · C8 + 99.19 · C48	−0.48 ± 11.14	8.28 ± 7.19
	98.53	136.35 + 4.79 · C1 + 13.56 · C6 + 104.09 · C48	−0.13 ± 10.49	7.95 ± 6.56
	98.52	419.84 + 4.74 · C1 + 10.61 · C5 + 105.38 · C48	−0.72 ± 12.40	9.52 ± 7.64
TRAC-HYD	99.67	−325.60 + 4.32 · C3 + 19.95 · C10 + 54.10 · C48	0.06 ± 5.30	3.59 ± 3.79
	99.62	−95.49 + 10.37 · C5 + 17.03 · C24 + 61.66 · C48	0.20 ± 5.18	4.10 ± 3.02
	99.61	−291.70 + 5.04 · C4 + 16.76 · C10 + 58.37 · C48	−0.27 ± 4.66	3.53 ± 2.93
	99.50	−86.96 + 5.60 · C1 + 13.39 · C5 + 82.56 · C48	−0.42 ± 6.77	4.32 ± 5.12
	99.49	−278.72 + 10.30 · C5 + 6.28 · C8 + 76.42 · C48	−0.20 ± 7.00	5.06 ± 4.67
	99.47	−278.81 + 3.38 · C2 + 23.11 · C10 + 51.83 · C48	−0.34 ± 6.46	4.84 ± 4.13
	99.46	−282.93 + 1.98 · C2 + 13.70 · C5 + 80.83 · C48	−0.20 ± 6.28	4.77 ± 3.91
	99.37	−290.92 + 2.08 · C3 + 12.94 · C5 + 80.27 · C48	−0.13 ± 6.34	4.80 ± 3.97
	99.33	−87.01 + 10.76 · C6 + 23.53 · C24 + 51.14 · C48	0.38 ± 6.54	5.13 ± 3.89
	99.33	137.54 + 5.09 · C4 + 10.56 · C8 + 75.26 · C48	−0.87 ± 6.71	5.12 ± 4.24