TABLE 6.
Pharmacokinetic parameters of itraconazole in healthy volunteersa
| Authors | Cmax (ng · ml−1) | AUC0–∞ (ng · h · ml−1) | Tmax (h) | t1/2 (h) |
|---|---|---|---|---|
| Hardin et al. (6) | 272 (81) | 4.16 (1.95) | 3.0 (0.7) | 21.0 (9.0) |
| van Peer et al. (20) | 289 (100) | 5.21 (2.12) | 4.7 (1.4) | 18.0 (4.0) |
| Schäfer-Korting et al. (17) | 319 (132) | 5.75 (2.24) | 4.0 (1.4) | 22.5 (7.8) |
| Barone et al. (1) | 239 (85) | 3.41 (1.15) | 4.5 )1.1) | 20.6 (5.4) |
| Present study | 242 (149) | 3.19 (2.41) | 3.6 (1.1) | 20.8 (8.9) |
a
Itraconazole capsules (200 mg) were taken after breakfast. Data are presented as means (standard deviations).