Table 1.

Summary of Recommendations for Administration of Monoclonal Antibodies

Risk for Severe COVID-19	Condition	Recommendation
		Treatment	Postexposure Prophylaxis
Highest risk	•\tObesity •\tSevere immunocompromisea •\tMedical complexity with respiratory technology dependence	Suggest use	Consider if high-risk exposure and unvaccinated or unlikely to mount an adequate response to vaccine
Moderate risk	•\tMild to moderate immunocompromisea •\tChronic respiratory conditions •\tCongenital heart disease •\tSickle cell disease	Consider use	Insufficient evidence
Lower risk	•\tDiabetes •\tChronic kidney disease	Suggest no routine use

Refer to text for examples of severe or mild to moderate immunocompromise.