Table 2.
Clinical and Metadata of the B.1.2, Alpha, and Delta infected patients
| B.1.2 | Alpha | Delta | P Value: Alpha to B.1.2 | P Value: Delta to Alpha | |
|---|---|---|---|---|---|
| Total | 377 | 1482 | 785 | ||
| Asymptomatic (%) | 80 (21.2) | 211 (14.2) | 108 (13.76) | .0015 | .7511 |
| Symptomatic (%) | 297 (78.8) | 1257 (84.8) | 675 (85.98) | ||
| All positives after vaccination (%) | 39 (10.3) | 184 (12.4) | 300 (38.2) | ||
| Confirmed breakthrough (%) | 2 (0.5) | 59 (4) | 224 (28.5) | .0002 | <.00001 |
| Median days after first dose (all positives after vaccination) | 9.4 | 20.1 | 178.4 | <.00001 | <.00001 |
| Median age (SD) | 45 (21.8) | 36 (21.3) | 38 (22.4) | <.00001 | .053 |
| Female (%) | 140 (37.1) | 865 (58.4) | 450 (57.3) | <.00001 | .623 |
| Male (%) | 237 (62.9) | 616 (41.6) | 335 (42.7) | ||
| Race | |||||
| Asian (%) | 24 (6.4) | 34 (2.3) | 47 (6) | ||
| Black (%) | 108 (28.6) | 860 (58) | 492 (62.7) | <.00001 | .0003 |
| White (%) | 209 (55.4) | 416 (28.1) | 333 (42.4) | ||
| Other/unknown (%) | 32 (8.5) | 172 (11.6) | 111 (14.1) | ||
| Disease severity | |||||
| Mortality (%) | 3 (0.8) | 16 (1.1) | 20(2.5) | .78 | .01 |
| Admission (%) | 28 (7.4) | 165 (11.1) | 122 (15.5) | .0372 | .003 |
| ICU (%) | 5 (1.3) | 54 (3.6) | 41 (5.2) | .0204 | .08 |
| Comorbidities | |||||
| Hypertension (%) | 128 (33.9) | 460 (31) | 230 (29.3) | .2918 | .41 |
| Respiratory failure (%) | 18 (4.8) | 159 (10.7) | 82 (10.4) | .0002 | .88 |
| Pregnancy (%) | 24 (6.4) | 118 (7.9) | 53 (6.8) | .3295 | .32 |
| Lung disease (%) | 83 (22) | 358 (24.2) | 124 (15.8) | .416 | <.00001 |
| Kidney disease (%) | 40 (10.6) | 204 (13.8) | 82 (10.4) | .1238 | .024 |
| Immunosuppression (%) | 68 (18) | 251 (16.9) | 117 (14.9) | .6462 | .23 |
| Diabetes (%) | 50 (13.3) | 235 (15.9) | 108 (13.8) | .2301 | .2 |
| Heart failure (%) | 17 (4.5) | 120 (8.1) | 44 (5.6) | .0152 | .03 |
| Atrial fibrillation (%) | 15 (3.9) | 65 (4.4) | 43 (5.5) | .8869 | .26 |
| Smoker (%) | 34 (9) | 212 (14.3) | 72 (9.2) | .0063 | .0004 |
| Cerebrovascular disease (%) | 26 (6.9) | 104 (7) | 53 (6.8) | 1 | .86 |
| Cancer (%) | 125 (33.2) | 318 (21.5) | 175 (22.3) | <.00001 | .67 |
| Coronary artery disease (%) | 55 (14.6) | 236 (15.9) | 93 (11.8) | .5786 | .009 |
Statistics for ages and median days after vaccination were calculated by t test, and all other statistics were calculated by χ2 test.
Abbreviations: ICU, intensive care unit; SD, standard deviation.