Table 5.
The relation between the different genotype variants of OLR1 rs1050286 3′UTR 188C> T gene with clinical characteristics laboratory finding, number of diseased vessels, risk scores, and outcomes in STEMI patients.
| Carriers of CC | Carriers of CT | Carriers of TT | CC vs.CT | CC vs. TT | CT vs. TT | |
|---|---|---|---|---|---|---|
| (n= 24) | (n= 100) | (n= 68) | P1 | P2 | P3 | |
| Age (years) | 60.6±7.2 | 56.8±9.3 | 53.8±8.5 | 0.078 | 0.944 | 0.036* |
| BMI (Kg/m²) | 26.9±9.2 | 35.8±6.9 | 29.6±9.2 | 0.004** | 0.958 | <0.001*** |
| Smoking N (%) | ||||||
| Yes | 10 (41.7%) | 57 (57%) | 34 (50%) | 0.176 | 0.482 | 0.371 |
| No | 14 (58.3%) | 43 (43%) | 34 (50%) | |||
| Smoking index (pack/year) | 83.5±6.9 | 87.3±24 | 72.7±38 | 0.181 | 0.019* | 0.02* |
| Diabetes N (%) | ||||||
| Yes | 4 (16.7%) | 16 (16%) | 28 (41.2%) | 0.936 | 0.03* | 0.001** |
| No | 20 (83.3%) | 84 (84%) | 40 (58.8%) | |||
| Diabetes duration (years) | 3.5±0.1 | 12±3.9 | 6.5±1.7 | 0.02* | 0.005** | 0.003** |
| Hypertension N (%) | ||||||
| Yes | 4 (16.7%) | 16 (16%) | 8 (11.8%) | 0.936 | 0.540 | 0.441 |
| No | 20 (83.3%) | 84 (84%) | 60 (88.2%) | |||
| Heart rate (bpm) | 94.2±20 | 106.8±22.3 | 98.2±25 | 0. 133 | 0.004** | 0.023* |
| Systolic blood Pressure (mm Hg) | 120.4±24.3 | 134.8±26.8 | 139±39 | 0.001** | 0.002** | 0.522 |
| EF (%) | 51.8±9.4 | 49.4±10.7 | 49.5±8.6 | 0.658 | 0.448 | 0.112 |
| PASP (mm Hg) | 33.2±12.6 | 27.7±10.2 | 30.6±8.2 | 0.135 | 0.036* | 0.554 |
| Ox-LDL (ng/ml) | 715±235 | 997.1±252 | 823.3±293 | 0.517 | 0.372 | 0.035* |
| Troponin at Admission (ng/ml) | 0.04 (0.01) | 0.16 (1.2) | 1.1 (1.25) | 0.361 | <0.001*** | 0.001** |
| CPK at admission (U/L) | 250 (115) | 1084 (1531) | 987 (938) | 0.029* | <0.001*** | 0.115 |
| CPK_MB at Admission (IU/L) | 41 (59) | 100 (165) | 143 (147) | 0.001** | <0.001*** | 0.079 |
| TG (mg/dl) | 214.8±92 | 262.3±82 | 213.4±86 | 0.80 | 0.488 | 0.564 |
| Total cholesterol (mg/dl) | 191.3±41 | 264.5±87 | 219.8±70 | 0.230 | <0.001*** | <0.001*** |
| LDL-C (mg/dl) | 142.9±57.7 | 173.4±79 | 147.9±58.7 | 0.097 | 0.149 | 0.004** |
| HDL-C (mg/dl) | 44.5±6.6 | 47.5±7.4 | 47±6.3 | 0.352 | 0.950 | 0.133 |
| Creatinine (mg/dl) | 1±0.46 | 0.9±0.27 | 0.92±0.4 | 0.159 | 0.371 | 0.102 |
| Glucose (mg/dl) | 158±36 | 162.9±98 | 188.2±68.9 | 0.01* | 0.001** | 0.428 |
| HbA1c | 4.2 (2.8) | 5 (2) | 4.5 (3.1) | 0.158 | 0.886 | 0.208 |
| Number of Diseased vessels | ||||||
| One vessel | 20 (83.3%) | 35 (35%) | 42 (61.8%) | 0.002** | 0.331 | 0.002** |
| Two vessels | 0 (0.0%) | 44 (44%) | 18 (26.5%) | |||
| Three vessels | 4 (16.7%) | 21 (21%) | 8 (11.8%) | |||
| KILLIP Classification | ||||||
| I | 20 (83.3%) | 24 (24%) | 40 (58.8%) | <0.001*** | 0.10 | <0.001*** |
| II | 0 (0.0%) | 0 (40%) | 8 (11.8%) | |||
| III | 0 (0.0%) | 24 24%) | 4 (5.9%) | |||
| IV | 4 (16.7%) | 12 (12%) | 16 (23.5%) | |||
| TIMI score | ||||||
| Low | 12 (50%) | 0 (0.0%) | 24 (35.3%) | <0.001*** | 0.415 | <0.001*** |
| Intermediate | 4 (16.7%) | 20 (20%) | 12 (17.6%) | |||
| High | 8 (33.3%) | 80 (80%) | 32 (47.1%) | |||
| GRACE risk score | ||||||
| Low | 16 (66.7%) | 8 (8%) | 20 (29.4%) | <0.001*** | 0.004** | <0.001*** |
| Intermediate | 4 (16.7%) | 16 (16%) | 16 (23.5%) | |||
| High | 4 (16.7%) | 76 (76%) | 32 (47.1%) | |||
| Mace | ||||||
| Heart Failure | 0 (0.0%) | 19 (57.6%) | 8 (66.7%) | 0.002** | 0.038* | 0.462 |
| Myocardial Reinfarction | 0 (0.0%) | 3 (100%) | 0 (0.0%) | |||
| Cardiogenic Shock | 0 (0.0%) | 8 (24.2%) | 4 (33.3%) | |||
| Cerebrovascular Stroke | 0 (0.0%) | 3 (100%) | 0 (0.0%) | |||
| Arrhythmias | ||||||
| Atrial Fibrillation | 0 (0.0%) | 0 (0.0%) | 4 (5.9%) | 0.352 | 0.145 | 0.001** |
| Ventricular Tachycardia | 0 (0.0%) | 0 (0.0%) | 7 (10.3%) | |||
| Heart Block | 0 (0.0%) | 2 (3%) | 4 (5.9%) | |||
| Asystole | 0 (0.0%) | 1 (1%) | 1 (1.5%) | |||
| In hospital mortality | ||||||
| Yes | 0 (0.0%) | 6 (6%) | 4 (5.9%) | 0.219 | 0.224 | 0.975 |
| No | 24 (100%) | 94 (94%) | 64 (94.1%) | |||
Data presents as mean±SD or median (IQR) and range.
BMI: Body mass index; EF: ejection fraction; PASP: pulmonary arterial systolic pressure; Ck: creatine kinase; HbA1c: glycosylated hemoglobin, MACE: major adverse cardiovascular events
*
Statistically significant difference (p< 0.05)
**
Statistically significant difference (p< 0.01).
***
Statistically significant difference (p< 0.001).