Table 1.
Baseline characteristics, lab tests, medication and follow-up parameters of the study groups
| All patientsN: 944 | COVID-19 groupN: 523 | Control groupN: 421 | P | ||
|---|---|---|---|---|---|
| Age, years, mean ± SD | 46.0 ± 12.0 | 45.0 ± 12.0 | 46.0 ± 12.0 | 0.726 | |
| Gender, n/N (%)a | Male | 532/944 (56.4) | 303/523(57.9) | 229/421 (54.4) | 0.276 |
| Smoking status, n (%) | Never smoked | 621/885 (70.2) | 339/494 (68.6) | 282/391 (72.1) | 0.410 |
| Current smoker | 25/885 (2.8) | 13/494 (2.6) | 12/391 (3.1) | ||
| Former smoked | 239/885 (27.0) | 142/494 (28.7) | 97/391 (24.8) | ||
| Tx duration, years, median (IQR) | 6.0 (3.0–11.1) | 6.6 (3.0–11.2) | 6.0 (3.0–11.0) | 0.414 | |
| Donor type, n (%) | Living non-related | 90/944 (9.5) | 50/523 (9.6) | 40/421 (9.5) | 0.068 |
| Living related | 638/944 (67.6) | 368/523 (70.4) | 270/421 (64.1) | ||
| Deceased | 216/944 (22.9) | 105/523 (20.1) | 111/421 (26.4) | ||
| BMI kg/m2, median (IQR) | 25.7 (23.8–28.1) | 25.9 (23.7–28.4) | 25.43 (22.9–27.9) | 0.019 | |
| Systolic BP, mmHg, median (IQR) | 130.0 (120.0–135.0) | 130.0 (120.0–133.0) | 130.0 (120.0–135.0) | 0.464 | |
| Diastolic BP, mmHg, median (IQR) | 80.0 (70.0–85.0) | 80.0 (70.0–85.0) | 80.0 (74.0–85.0) | 0.488 | |
| Creatinine, mg/dl, median (IQR) | 1.3 (1.0–1.6) | 1.3 (1.0–1.7) | 1.2 (1.0–1.5) | <0.001 | |
| AST, U/L, median (IQR) | 17.0 (14.0–22.0) | 17.5 (14.0–24.0) | 17.0 (13.0–21.0) | 0.018 | |
| ALT, U/L, median (IQR) | 17.0 (12.0–22.0) | 17.0 (13.0–24.0) | 16.0 (12.0–21.0) | 0.039 | |
| LDH, U/L, median (IQR) | 200.0 (163.0–247.0) | 206.0 (166.0–254.0) | 193.0 (160.0–236.0) | 0.014 | |
| Albumin, g/dL, median (IQR) | 4.2 (4.0–4.5) | 4.2 (3.9–4.5) | 4.3 (4.0–4.6) | 0.001 | |
| Ferritin, ng/mL, median (IQR) | 120.0 (43.1–295.9) | 136.0 (5.0–327.5) | 98.5 (38.0–252.0) | 0.022 | |
| CRP, mg/L, median (IQR) | 3.9 (2.1–10.0) | 15.0 (2.0–16.2) | 3.1 (1.7–5.6) | <0.001 | |
| Leukocyte counts/mm3, median (IQR) | 7400 (5895–9255) | 7200 (5600–8903) | 7600 (6100–9480) | 0.008 | |
| Neutrophil counts/mm3, median (IQR) | 4640 (3540–5960) | 4600 (3500–5800) | 4700 (3600–6270) | 0.124 | |
| Lymphocyte counts (/mm3), median (IQR) | 1775 (1185–2375) | 1600(1100–2300) | 1900 (1340–2500) | <0.001 | |
| Proteinuria (mg/mg), median (IQR) | 228.1 (117.5–564.9) | 280.0 (127.5–700.7) | 188.2 (103.7–467.5) | 0.001 | |
| Hemoglobin (g/dL), median (IQR) | 12.9 (11.3–14.2) | 12.8 (11.1–14.0) | 13.0 (11.6–14.4) | 0.013 |
P-values presented from the Chi-squared test, Fisher's exact test, t-test or Mann–Whitney U test.
aCompared with female gender.
IQR, interquartile range; BMI, body mass index; BP, blood pressure; CRP, C-reactive protein; LDH, lactate dehydrogenase; AST, aspartate aminotransferase; ALT, alanine aminotransferase.