Table 1.
Demographic and clinical characteristics of the patient cohort and their association with Thr92Ala-DIO2 polymorphism and mortality (n = 220)
| Variables | Mann–Whitney test and Cochran–Armitage test | Univariate logistic regression Mortality | ||||||
|---|---|---|---|---|---|---|---|---|
| Total | Thr/Thr | Thr/Ala | Ala/Ala | P | OR | IC 95% | P | |
| (n = 220) | (n = 78) | (n = 119) | (n = 23) | |||||
| Age (y), median (IQR) | 62 (48-74) | 63 (51-75) | 60 (47-74) | 63 (47-77) | .539 | 1.016 | 0.993-1.040 | .176 |
| BMI(kg/m2) | 29.8 (26-34) | 29.8 (27-33) | 29.8 (25-34) | 29.4 (26-34) | .923 | 0.993 | 0.938-1.050 | .859 |
| Age > 60 year, n (%) | 116 (52.7) | 43 (56.5) | 60 (50.4) | 13 (56.5) | .501 | 1.467 | 0.725-3.044 | .291 |
| Gender male, n (%) | 135 (61.3) | 41 (52.5) | 79 (66.4) | 15 (65.2) | .16 | 0.647 | 0.319-1.318 | .226 |
| Length of hospital stay (d), median (IQR) | 6 (4-10) | 7 (4-11) | 6 (4-10) | 6 (4-12) | .611 | 1.099 | 1.052-1.154 | <.0001 |
| Comorbidities | ||||||||
| Hypertension, n (%) | 144 (65.4) | 58 (74.3) | 72 (60.5) | 14 (60.9) | .049 | 1.175 | 0.565-2.559 | .672 |
| Diabetes mellitus, n (%) | 93 (42.3) | 33 (42.3) | 51 (42.8) | 9 (39.1) | .881 | 1.352 | 0.661 -2.755 | .405 |
| Cardiopathy, n (%) | 28 (12.7) | 12 (15.4) | 15 (12.6) | 1 (4.3) | .628 | 0.333 | 0.052-1.187 | .146 |
| Chronic pneumopathy, n(%) | 10 (4.5) | 5 (6.4) | 4 (3.3) | 1 (4.3) | .317 | 0.51 | 0.027-2.891 | .540 |
| Neoplasia, n (%) | 2 (0.9) | 0 (0) | 1 (0.8) | 1 (4.3) | .631 | 4.89 | 0.190-125.5 | .265 |
| Obesity, n (%)a | 103 (49) | 37 (49) | 55 (49.1) | 11 (47.8) | .982 | 0.39 | 0.169-0.852 | .021 |
| Complications | ||||||||
| NTIS, n (%) | 14 (6.4) | 4 (5.1) | 7 (5.9) | 3 (13) | .055 | 4.1 | 1.268-12.5 | .0142 |
| Cardiovascular shock, n (%) | 28 (12.7) | 12 (15.4) | 13 (10.9) | 3 (13) | .357 | 54.2 | 19.3-181.4 | <.0001 |
| Endotracheal intubation, n (%) | 29 (13.2) | 14 (17.9) | 12 (10) | 3 (13) | .111 | 129.3 | 39-600 | <.0001 |
| ICU admission, n (%) | 55 (25) | 24 (30.7) | 26 (21.8) | 5 (21.7) | .37 | 36.8 | 14.8-106.9 | <.0001 |
| Scores systems | ||||||||
| NEWS2 score, median (IQR) | 6 (5 -7) | 5 (4-6) | 6 (5 -7) | 6 (5 -7) | .346 | 1.162 | 0.960-1.348 | .134 |
| q-SOFA score, median (IQR) | 1 (1-1) | 1 (1-1) | 1 (0-1) | 1 (1-1) | .435 | 1.897 | 0.892-4.256 | .105 |
| CT COVID score, median (IQR) | 20 (15-20) | 20 (15-20) | 20 (15-20) | 20 (15-20) | .786 | 1.043 | 0.972-1.133 | .277 |
Mann–Whitney test was performed for continuous variables (age, NEWS2, qSOFA and CT COVID score) while Cochran–Armitage test was performed for all other variables.
Abbreviations: BMI, body mass index; CT, computed tomography; ICU, intensive care unit; IQR, interquartile range; NEWS2, National Early Warning Score 2; NTIS, nonthyroid illness syndrome; qSOFA, quick Sepsis-related Organ Failure Assessment.
a (n = 210 patients).