Table 2.
Blood biochemistry in COVID-19 patients and their association with Thr92Ala-DIO2 polymorphism and mortality
| Kruskal–Wallis test median (IQR) | Univariate logistic regression mortality | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Parameters (normal range) | Total | A (Thr/Thr) | B (Thr/Ala) | C (Ala/Ala) | P | Benjamini–Hochberg’s | OR | IC 95% | P |
| (n = 221) | (n = 79) | (n = 119) | (n = 23) | test | |||||
| TSH (0.4-5.8 µIU/mL) | 1.66 (0.9-3) | 1.55 (0.9-3) | 1.62 (0.9-2.9) | 2.15 (1.0-3.8) | .322 | 0.986 | 0.796-1.193 | .895 | |
| fT4 (0.89-1.72 ng/dL) | 1.33 (1-1.6) | 1.3 (1-1.5) | 1.35 (1.0-1.7) | 1.28 (0.8-1.5) | .465 | 1.011 | 0.497-1.989 | .975 | |
| fT3 (2.0-4.2 pg/mL) | 2.96 (2.6-3.4) | 2.92 (2.6-3.3) | 3.14 (2.6-3.5) | 2.77 (2.1-3.2) | .029 | A-B (P = .054) B-C (P = .023) |
0.460 | 0.276-0.739 | .002 |
| rT3 (0.1-0.35 ng/mL) | 0.48 (0.3-0.6) | 0.38 (0.2-0.6) | 0.52 (0.3-0.6) | 0.53 (0.3-0.6) | .249 | 0.086 | 0.013-0.461 | .006 | |
| Thyroglobulin (1.59- 59.9 ng/mL) | 15.1 (6-26) | 15.6 (6-28.7) | 14.5 (6-23) | 15.8 (6-45) | .725 | 0.994 | 0.976-1.005 | .414 | |
| FT3/RT3 | 6.60 (4.6-9.9) | 7 (4.7-10.6) | 6.61 (4.7-9.8) | 4.83 (3.7-6.7) | .056 | B-C(P = .045) A-C (P = .016) | 1.017 | 0.963-1.067 | .496 |
| FT3●RT3 | 1.28 (0.8-2.1) | 1.1 (0.7-1.9) | 1.46 (0.8-2.3) | 1.24 (0.7-1.9) | .075 | A-B (P = .025) | 0.441 | 0.249-0.717 | .002 |
| FT4/FT3 | 0.43 (0.3-0.5) | 0.45 (0.3-0.5) | 0.43 (0.3-0.5) | 0.48 (0.3-0.6) | .691 | 9.697 | 1.737-57.4 | .01 | |
| IL-6 (<3.4 pg/mL) | 49.8 (21-87) | 43 (23-83) | 55.5 (23-96) | 32.8 (19-84) | .533 | 1.000 | 0.999-1.001 | .739 | |
| D-dimer (<500 ng/mL) | 759 (487-1628) | 924 (546-1579) | 696 (458-1496) | 706 (488-3629) | .447 | 1.000 | 1.000-1.000 | .047 | |
| LDH (207-414 U/L) | 742 (538-1014) | 723 (522-1006) | 772(564-1051) | 718 (488-992) | .529 | 1.001 | 1.000-1.002 | .008 | |
| Creatinine (mg/dL) | 1.1 (0.9-1.3) | 1.13 (0.9-1.4) | 1.1 (0.8-1.3) | 1.0 (0.9-1.3) | .342 | 1.017 | 0.754-1.197 | .851 | |
| CRP (<5.0 mg/dL) | 83 (36-151) | 68 (30-145) | 100 (42-162) | 75.3 (33-142) | .337 | 1.009 | 1.004-1.015 | .002 | |
| ALT (8-42 U/L) | 62 (39-102) | 53 (38-97) | 68 (46-111) | 48 (23-114) | .06 | A-B(P = .046) | 0.992 | 0.984-0.999 | .067 |
| AST (8-42 U/L) | 54 (38-80) | 49 (36-77) | 56 (40-84) | 52 (33-75) | .206 | 0.996 | 0.988-1.003 | .382 | |
| Neutrophils (1935-6700 103 cells/µL) | 7412 (5348-10130) | 7701(5237-9290) | 7303 (5340-10660) | 7560 (5642-9945) | .978 | 1.000 | 1.000-1.000 | .053 | |
| Hemoglobin (13-18 g/dL) | 13.4 (12-14.4) | 13 (11-14) | 13.6 (12-14) | 13.3 (12-14) | .032 | A-B(P = .009) | 0.816 | 0.680-0.978 | .027 |
| N/L ratio (1-3) | 9.27 (5.8-14) | 9.5 (5.8-14) | 9.11 (6-14) | 10.5 (5.2-14) | .954 | 1.077 | 1.025-1.135 | .004 | |
| Albumin (3.5-5.5 g/dL) | 3.3 (2.9-3.7) | 3.3 (2.9-3.7) | 3.3 (2.9-3.7) | 3.2 (2.7-3.4) | .609 | 0.328 | 0.158-0.653 | .002 | |
Kruskal–Wallis test and univariate logistic regression (mortality) were performed for all variables.
Abbreviations: ALT, alanine transaminase; AST, aspartate transaminase; CI, confidence interval; CRP, C-reactive protein; fT3, free triiodothyronine; fT4, free thyroxine; IL-6, interleukin 6; IQR, interquartile range; LDH, lactate dehydrogenase; N/L ratio, neutrophil–lymphocyte ratio; OR, odds ratio; rT3, reverse triiodothyronine; TSH, thyrotropin.