Table 3.

Multivariable regression analyses of mortality, considering multiple covariates, Thr92Ala-DIO2 polymorphism, and overdominant inheritance model

				Ala/Thr vs Ala/Ala			Ala/Thr vs Thr/Thr			Thr/Thr vs Ala/Ala			Ala/Thr vs Ala/Ala + Thr/Thr (Overdominant model)
				OR*	CI 95%	P	OR*	CI 95%	P	OR*	CI 95%	P	OR*	CI 95%	P
			Mortality	0.52	0.18-1.75	.26	0.49	0.23-1.04	0.06	1.06	0.36-3.57	.9	0.52	0.26-1.04	0.07
Model 5	Model 4	Model 1	Male gender	0.52	0.18-1.76	.26	0.49	0.23-1.04	0.06	1.06	0.36-3.57	.9	0.52	0.26–1.04	0.07
			Age > 60 year	0.53	0.18-1.79	.27	0.50	0.23-1.06	0.07	1.07	0.36-3.59	.9	0.53	0.26–1.06	0.07
			Diabetes	0.48	0.16-1.62	.20	0.45	0.21-0.98	0.04	1.05	0.36-3.53	.9	0.49	0.23–0.98	0.047
			Hypertension	0.52	0.18-1.75	.26	0.49	0.23-1.06	0.07	1.05	0.36-3.55	.9	0.53	0.26–1.06	0.08
			Hospital stay	0.47	0.15-1.65	.21	0.48	0.21-1.07	0.07	0.97	0.32-3.39	1.0	0.51	0.24–1.05	0.07
			Model 1	0.43	0.14-1.54	.17	0.43	0.19-0.99	0.048	0.99	0.32-3.51	1.0	0.46	0.21–0.98	0.046
		Model 2	TSH	0.51	0.17-1.72	.24	0.49	0.23-1.03	0.06	1.04	0.35-3.51	.9	0.52	0.26–1.05	0.07
			Free T3	0.74	0.24-2.65	.62	0.54	0.25-1.16	0.12	1.37	0.44-4.87	.6	0.62	0.3–1.28	0.20
			Free T4	0.51	0.17-1.74	.25	0.49	0.23-1.03	0.06	1.06	0.36-3.55	.9	0.52	0.25–1.04	0.07
			Reverse T3	0.48	0.16-1.66	.22	0.54	0.25-1.17	0.12	0.89	0.29-3.07	.8	0.56	0.27–1.13	0.11
			Model 2	0.61	0.19-2.24	.42	0.56	0.25-1.22	0.14	0.92	0.25-1.22	.9	0.64	0.3–1.32	0.23
		Model 3	IL-6	0.51	0.17-1.73	.25	0.49	0.23-1.04	0.06	1.05	0.26-3.52	.9	0.52	0.25–1.04	0.07
			CRP	0.55	0.16-2.19	.36	0.41	0.18-0.9	0.03	1.34	0.4-5.36	.6	0.46	0.21–0.96	0.04
			D-DIMER	0.57	0.19-1.97	.34	0.51	0.23-1.11	0.09	1.12	0.37-3.85	.9	0.55	0.27–1.13	0.11
			Neutrophil	0.47	0.16-1.61	.20	0.44	0.2-0.96	0.04	1.06	0.36-3.59	.9	0.48	0.23–0.97	0.04
			LDH	0.46	0.15-1.58	.19	0.47	0.21-1.05	0.07	0.97	0.32-3.33	1.0	0.49	0.23–1.03	0.06
			Model 3	0.52	0.14-2.2	.34	0.36	0.15-0.85	0.02	1.44	0.41-6.08	.6	0.42	0.18–0.92	0.03
			Model 4	0.46	0.12-2.04	.27	0.32	0.12-0.8	0.02	1.43	0.38-6.41	.6	0.38	0.16–0.87	0.03
			Model 5	0.56	0.13-2.85	.46	0.32	0.12-0.85	0.03	1.74	0.4-9.02	.5	0.40	0.16–0.98	0.049

Multivariable regression analyses: Model 1, adjusted for male gender, age >60 years, diabetes, arterial hypertension, and length of hospital stay. Model 2, adjusted for thyrotropin, free triiodothyronine, free thyroxine, and reverse triiodothyronine. Model 3, adjusted for interleukin-6, neutrophils, lactate dehydrogenase, C-reactive protein, and D-dimer. Model 4, adjusted for Model 1 and 3. Model 5, adjusted for all of the above variables.