Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 5;75(1):e928–e937. doi: 10.1093/cid/ciac184

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 4. — Interactive relationships between participant age, the relative abundances of specific bacterial ASVs in the nasopharyngeal microbiome, and SARS-CoV-2 status. A, Bar chart depicting differences in the mean relative abundance of ASV1163 (Corynebacterium propinquum) among SARS-CoV-2–infected participants relative to uninfected participants in different age categories. The line was constructed using the GJAM estimates for the association of SARS-CoV-2 infection with the relative abundance of ASV1163 (intercept) and the association of the interaction term between SARS-CoV-2 infection and age with the relative abundance of ASV1163 (slope). Higher relative abundances of ASV1163 were observed in SARS-CoV-2–infected compared with uninfected participants across all ages, but these differences were more pronounced in young children. B, Differences in mean relative abundance of ASV336 (Moraxella lincolnii) between SARS-CoV-2–infected participants with respiratory symptoms and SARS-CoV-2–infected participants without respiratory symptoms are depicted by age category. Dark (light) gray bars represent age categories in which ASV336 was more (less) abundant among SARS-CoV-2–infected participants with respiratory symptoms compared with SARS-CoV-2–infected participants without respiratory symptoms. The line was constructed using the GJAM estimates for the association of SARS-CoV-2–associated respiratory symptoms with the relative abundance of ASV336 (intercept) and the association of the interaction term between respiratory symptoms and age with the relative abundance of ASV336 (slope). The difference in the mean relative abundance of ASV336 between SARS-CoV-2–infected participants with and without respiratory symptoms differed by age, such that this ASV was less abundant in the context of SARS-CoV-2–associated respiratory symptoms among young children and more abundant in the context of SARS-CoV-2–associated respiratory symptoms in older age groups. Lines were fit using the regression coefficients generated using GJAM. Age is shown as a categorical variable only for graphical representation; all statistical analyses included age as a continuous variable. Abbreviations: ASV, amplicon sequence variant; GJAM, generalized joint attribute modeling; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.

HHS Vulnerability Disclosure