TABLE 1.
Drug concentrations in serum and each genital tissue after oral administration of 150 mg of fluconazole
| Patient | Time after administration (h) | Concn (μg/ml) in serum from:
|
Concn (μg/g) in tissue from:
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Uterine artery | Antecubital vein | Portio vaginalis | Cervix uteri | Endometrium | Myometrium | Oviduct | Ovary | ||
| 1 | 1.83 | 3.6 | 3.7 | 3.0 | 3.1 | 3.2 | 3.4 | 3.4 | NTa |
| 2 | 2.08 | 3.0 | 2.7 | 2.6 | 2.7 | 2.6 | 2.5 | 2.6 | NT |
| 3 | 2.50 | 4.1 | 4.1 | 4.1 | 4.6 | 4.2 | 4.3 | 3.9 | 4.0 |
| 4 | 2.57 | 3.7 | 3.8 | 3.6 | 3.6 | 3.8 | 4.3 | 4.4 | 4.3 |
| 5 | 2.57 | 2.1 | 1.9 | 2.1 | 1.7 | 1.8 | 2.2 | 1.9 | NT |
| 6 | 2.58 | 3.9 | 3.8 | 3.2 | 3.2 | NT | 2.8 | 4.5 | 4.3 |
| 7 | 2.67 | 3.5 | 3.6 | 4.1 | 3.2 | 4.5 | 3.8 | 4.4 | NT |
| 8 | 2.67 | 2.3 | 2.5 | 2.3 | 2.3 | NT | 2.3 | 4.2 | 2.6 |
| 9 | 2.75 | 4.3 | 4.3 | 3.8 | 4.5 | NT | 4.6 | 4.2 | 4.7 |
| 10 | 2.83 | 3.3 | 3.2 | 2.3 | 2.8 | 3.5 | 3.0 | 3.4 | 3.2 |
| 11 | 3.08 | 1.5 | 1.5 | 1.2 | 1.4 | 1.3 | 1.5 | 1.2 | 1.3 |
| 12 | 3.17 | 4.0 | 4.1 | 4.2 | 3.8 | 5.3 | 4.7 | 5.2 | 4.6 |
| 13 | 4.25 | 3.1 | 3.5 | 3.3 | 3.7 | 4.2 | 3.2 | 4.3 | 3.4 |
| 14 | 6.00 | 3.7 | 3.8 | 3.9 | 3.3 | 3.6 | 3.8 | 4.1 | NT |
| 15 | 9.33 | 4.1 | 4.0 | 4.0 | 3.6 | NT | 4.3 | NT | 3.2 |
| 16 | 10.42 | 3.4 | 3.5 | 3.2 | 3.2 | 3.3 | 3.4 | 3.6 | NT |
| 17 | 11.50 | 3.0 | 2.9 | 2.4 | 2.6 | 2.8 | 2.8 | NT | NT |
| 18 | 13.00 | 4.5 | 4.5 | 4.5 | 3.1 | 5.7 | 5.4 | 4.9 | NT |
| 19 | 13.00 | 3.4 | 3.2 | 3.4 | 2.8 | 3.6 | 3.2 | 4.4 | 3.4 |
| 20 | 13.50 | 3.2 | 3.4 | 3.4 | 3.1 | NT | 3.4 | 3.6 | 3.3 |
| 21 | 14.00 | 3.7 | 3.7 | 4.0 | 3.5 | NT | 3.7 | 4.4 | 3.6 |
| 22 | 14.50 | 3.4 | 3.3 | NT | 3.2 | 3.8 | 3.5 | 4.1 | 3.7 |
| 23 | 17.25 | 3.7 | 3.7 | 3.5 | 3.3 | 3.4 | 3.5 | 3.8 | NT |
| 24 | 19.25 | NT | 3.6 | NT | NT | NT | NT | NT | NT |
| 25 | 21.50 | 3.6 | 3.4 | 3.3 | NT | NT | 3.2 | 3.7 | 3.4 |
| 26 | 21.50 | 3.5 | NT | 2.9 | NT | NT | 3.4 | 2.8 | 3.8 |
| 27 | 22.67 | 3.2 | 3.2 | 3.0 | NT | NT | 2.9 | 3.7 | NT |
| 28 | 23.17 | 2.0 | 2.2 | 1.9 | 2.0 | 2.3 | 2.2 | 2.3 | 2.1 |
| 29 | 24.25 | 2.6 | 2.7 | 2.7 | 2.6 | 2.9 | 2.9 | NT | NT |
| 30 | 24.57 | 2.3 | 2.3 | 2.4 | 2.4 | 2.6 | 2.7 | 2.4 | NT |
| 31 | 24.83 | 2.5 | 2.5 | 2.0 | 2.4 | 2.4 | 2.7 | NT | NT |
| 32 | 26.00 | 2.8 | 2.8 | 3.2 | 2.4 | 2.6 | 2.9 | 3.3 | NT |
| 33 | 26.33 | 2.8 | 2.6 | 2.4 | 2.4 | 2.6 | 2.5 | 2.8 | NT |
| 34 | 27.50 | NT | 3.5 | 4.3 | NT | NT | 5.1 | 4.1 | 3.4 |
| 35 | 31.25 | 2.2 | 2.2 | 2.1 | 2.2 | NT | 2.2 | 2.1 | 1.9 |
| 36 | 37.00 | 1.9 | 1.8 | 2.1 | 2.0 | NT | 2.4 | 2.2 | 2.1 |
| 37 | 37.50 | 2.3 | 2.2 | NT | 2.1 | NT | 2.3 | 2.9 | 2.4 |
| 38 | 37.50 | 1.6 | 1.5 | 1.5 | 1.8 | 1.3 | 1.5 | 1.4 | 1.5 |
| 39 | 39.50 | NT | 1.6 | 1.6 | 1.4 | 1.7 | 1.5 | 1.5 | 1.5 |
| 40 | 41.50 | 1.4 | 1.3 | 1.3 | 1.5 | 1.5 | 1.4 | 1.7 | 1.6 |
| 41 | 41.50 | 2.3 | 2.1 | NT | NT | NT | 1.9 | 2.1 | 2.0 |
| 42 | 41.67 | 1.5 | 1.5 | 1.5 | 1.4 | NT | 1.7 | 1.6 | 1.5 |
| 43 | 41.83 | 2.2 | 2.2 | 1.6 | 2.2 | 1.9 | 2.1 | 2.4 | 2.0 |
| 44 | 42.00 | 3.8 | 3.5 | 3.2 | NT | NT | 3.5 | 4.1 | 3.9 |
| 45 | 43.50 | 1.5 | 1.4 | 1.6 | 1.6 | NT | 1.8 | 1.8 | 1.6 |
| 46 | 45.50 | NT | NT | 1.2 | 1.3 | 1.3 | 1.5 | NT | NT |
| 47 | 46.17 | NT | 2.0 | NT | NT | NT | NT | NT | NT |
| 48 | 49.50 | NT | 1.2 | 1.2 | 1.2 | 1.5 | 1.3 | 1.3 | 1.4 |
| 49 | 50.00 | 1.4 | 1.5 | 1.2 | 1.1 | 1.3 | 1.3 | 1.3 | 1.5 |
| 50 | 52.25 | 1.5 | 1.5 | 1.0 | 1.1 | 1.1 | 1.7 | 1.3 | 1.1 |
| 51 | 64.50 | NT | 1.8 | 2.1 | 1.8 | 1.5 | 1.6 | 1.6 | 1.4 |
| 52 | 68.50 | 1.1 | 1.0 | 0.8 | 0.8 | NT | 1.3 | 1.1 | 1.1 |
a
NT, not tested.