TABLE 2.
Pharmacokinetic parameters of 150 mg of orally administered fluconazole
| Tissue | Parmacokinetic parametera
|
|||
|---|---|---|---|---|
| Cmax (h) | Tmax (h) | t1/2 (h) | AUC0–∞ (μg/ · h/ml or g) | |
| Serum from cubital vein | 3.9 | 6.1 | 33.5 | 214 |
| Serum from uterine artery | 3.8 | 6.0 | 35.4 | 221 |
| Vagina | 3.8 | 6.8 | 30.0 | 194 |
| Cervix uteri | 3.5 | 5.3 | 33.0 | 186 |
| Corpus uteri | 4.0 | 6.2 | 33.9 | 223 |
| Endometrium | 4.1 | 6.2 | 25.5 | 180 |
| Oviduct | 4.5 | 6.6 | 29.1 | 222 |
| Ovary | 3.9 | 4.7 | 36.5 | 221 |
a
Cmax, maximum concentration of drug in serum; Tmax, time to maximum concentration of drug in serum; t1/2, half-life; AUC0–∞, area under the concentration-time curve from 0 h to infinity.