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. 2022 Feb 18;75(1):e630–e644. doi: 10.1093/cid/ciac103

Figure 2.

Figure 2.

A, Scatter plot of 50% neutralization titer (NT50) for D614G pseudovirus (x-axis) by anti-RBD antibody levels (signal to cut-off [S/CO] ratio) measured by Beckman assay (y-axis). NT50 was defined as the highest serum dilution that neutralizes >50% of the D614G pseudovirus. Black filled circles are data from nonimmunocompromised healthcare workers; red filled circles are data from immunocompromised participants. B, Comparisons of antibody levels and NT50 across 100 study participants. Black, blue, and red boxes represent participants with antibody levels <1, 1–10, and >10, respectively. Among participants with antibody S/CO levels 1–10, NT50 were significantly lower among IC participants compared with HCWs. Abbreviations: HCWs, healthcare workers; IC, immunocompromised; RBD, receptor-binding domain.