Table 2.
Seropositivity and Antibody Levels in HCWs and Immunocompromised Participants
| Outcome | HCWs (N = 172) | Immuno-compromised Patients (N = 1099) | P * | Patients by Immunocompromised Condition | P ** | ||||
|---|---|---|---|---|---|---|---|---|---|
| SOT (N = 450) | Autoimmune (N = 263) | Hematologic Malignancy (N = 156) | HIV (N = 94) | Solid Tumor (N = 136) | |||||
| Seropositivity, n (%) | 159 (92.4%) | 606 (55.1%) | <.001 | 138 (30.7%) | 208 (79.1%) | 78 (50.0%) | 75 (79.8%) | 107 (78.7%) | <.001 |
| Median antibody level (IQR) | 5.2 (2.5,11.5) | 1.6 (0.1,7.2) | <.001 | 0.1 (0.0,1.7) | 4.3 (1.5,10.8) | 1.3 (0.1,8.5) | 4.8 (1.6,12.5) | 5.7 (1.3,13.9) | <.001 |
| Categorical antibody level, n (%)a | <.001 | <.001 | |||||||
| 0 to < 5 | 84 (49.1%) | 736 (68.4%) | 386 (87.5%) | 138 (53.7%) | 99 (65.6%) | 49 (52.7%) | 64 (47.8%) | ||
| 5–10 | 36 (21.1%) | 131 (12.2%) | 27 (6.1%) | 49 (19.1%) | 16 (10.6%) | 18 (19.4%) | 21 (15.7%) | ||
| > 10 | 51 (29.8%) | 209 (19.4%) | 28 (6.3%) | 70 (27.2%) | 36 (23.8%) | 26 (28.0%) | 49 (36.6% | ||
Abbreviations: HCWs, healthcare workers; HIV, human immunodeficiency virus; IQR, interquartile range; SOT, solid organ transplant.
P value for comparison between HCWs and all immunocompromised patients (likelihood ratio χ2 test).
P value for comparison between patients by immunocompromised condition (likelihood ratio χ2 test).
Antibody levels and categories are defined by signal to cut-off ratio from the Beckman anti-receptor-binding domain assay.