Table 3.
Features at Long-term Follow-up (>180 Days From Initial Symptoms)
| Clinical Characteristics | Severe Disease (n = 128) | Moderate Disease (n = 147) | P Valuea |
|---|---|---|---|
| Symptom resolution, % | 37.96 | 27.35 | .089 |
| Symptoms, % | |||
| -Cough | 3.30 | 11.90 | .030 |
| -Chest pain | 4.35 | 13.95 | .025 |
| -Asthenia | 7.69 | 20.00 | .017 |
| -Memory loss | 4.55 | 3.95 | .850 |
| -Hair loss | 0.00 | 1.27 | .287 |
| Dyspnea mMRC, mean (SD), No. | 0.82 (0.07) | 0.89 (0.06) | .392 |
| Dyspnea mMRC ≥2, % | 20 | 18.42 | .249 |
| Crackly, % | 8.43 | 6.49 | .642 |
| Average time,b median (IQR), d | 300 (245–352) | 306 (254–363) | .352 |
| Radiological Features | Severe Disease (n = 117) | Moderate Disease (n = 147) | |
| Normal radiological pattern, % | 70.94 | 91.15 | .001 |
| RALE score, mean (SD) | 0.09 (0.05) | 0.00 (0.00) | .085 |
| RALE score 0, % | 97.06 | 99.35 | .176 |
| Pulmonary opacities, % | 10.34 | 2.19 | .006 |
| Parenchymal bands or reticulations, % | 21.05 | 7.25 | .001 |
| Hypoattenuation, % | 6.20 | 2.88 | .154 |
| Average time,b median (IQR), d | 260 (228–320) | 274 (225–353) | .262 |
| Pulmonary Functional Data | Severe Disease (n = 75) | Moderate Disease (n = 78) | |
|---|---|---|---|
| Functional data normalization, % | 50.66 | 64.10 | <.001 |
| FEV1, mean (SD), % predicted | 101.84 (21.38) | 103.70 (19.62) | .620 |
| FVC, mean (SD), % predicted | 103.44 (22.59) | 110.55 (20.55) | .074 |
| FEV/FVC, mean (SD), % | 78.46 (8.66) | 75.51 (7.53) | .033 |
| SpO2, mean (SD), % | 95.83 (4.05) | 97.18 (1.15) | .008 |
| DLCO, mean (SD), % predicted | 75.73 (24.68) | 83.79 (21.18) | .032 |
| Average time,b median (IQR), d | 277 (224–350) | 268 (218–344) | .609 |
| Serum Biomarkers | Severe Disease (n = 58) | Moderate Disease (n = 58) | |
|---|---|---|---|
| Lactate dehydrogenase, median (IQR), U/L | 366 (326–427) | 363 (316–410) | .445 |
| Ferritin, median (IQR), ng/mL | 114 (55.5–304.5) | 72.75 (45–143) | .047 |
| D-dimer, median (IQR), ng/mL | 415 (265–831) | 390 (242–502) | .374 |
| D-dimer >500 ng/mL, % | 36.36 | 25 | .131 |
| Average time,b median (IQR), d | 289 (273–306) | 275 (255–294) | .256 |
Abbreviations: DLCO, diffusion capacity for carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; IQR, interquartile range; mMRC, modified Medical Research Council; RALE, Radiographic Assessment of Lung Edema; SpO2, oxygen saturation.
P values from 2-sample t tests, Wilcoxon rank-sum test, chi-square test, or Fisher exact test. Average time from initial symptoms to evaluation.
Time from initial symptoms to the follow-up data.