Table 6.
Relationship Between D-dimer Features and Clinical Characteristics, COVID-19 Disease Severity and Features at Long-term Follow-up
| Abnormal D-dimer >500 ng/mL (n = 36) |
Normal D-dimer ≤500 ng/mL (n = 80) |
P Value | |
|---|---|---|---|
| Age, mean (SD), y | 72.34 (14.16) | 57.2 (12.53) | <.001 |
| Never-smoker, % | 62.50 | 61.54 | .554 |
| Pulmonary disease, % | 32.35 | 34.72 | .495 |
| Body mass index, mean (SD), kg/m2 | 30.46 (4.23) | 30.69 (6.12) | .950 |
| Length of hospital stay, median (IQR), d | 22 (10–32) | 14 (3–25) | .070 |
| Peak RALE score, mean (SD) | 4.62 (1.98) | 3.94 (2.47) | .186 |
| Peak D-dimer, median (IQR) | 5062 (1800–22 840) | 1748 (800–4568) | .020 |
| Severe disease, % | 57.14 | 43.75 | .131 |
| Features at long-term follow-up (>180 d) | |||
| mMRC dyspnea, mean (SD) | 1 (0.87) | 0.67 (0.59) | .066 |
| FEV/FVC, mean (SD), % | 74.85 (2.81) | 78.98 (1.00) | .349 |
| FEV1, mean (SD), % predicted | 96 (19.51) | 106.97 (18.80) | .028 |
| FVC, mean (SD), % predicted | 101.22 (25.86) | 110.65 (22.44) | .208 |
| SpO2, % | 96.09 | 97.04 | .018 |
| DLCO, mean (SD), % predicted | 71.73 (22.92) | 86.36 (20.83) | .006 |
| RALE score, mean (SD) | 0 (0) | 0.01 (0.11) | .505 |
Abbreviations: DLCO, diffusion capacity for carbon monoxide; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; IQR, interquartile range; mMRC, modified Medical Research Council; RALE, Radiographic Assessment of Lung Edema; SpO2, oxygen saturation.