Table 1.
Clinical characteristics of participants
| Migraine (n = 18) |
|
|---|---|
| Demographics (mean ± SD) | |
| Age | 39.0 ± 10.0 |
| Female (n, %) | 15 (79%) |
| BMI | 26.8 ± 6.2 |
| Educational level (University educated n, %) | 12 (63.1%) |
| Migraine Characteristics (mean ± SD) | |
| Duration (years) | 21.0 ± 11.0 |
| Aura (n, %) | 12.0 (66.7%) |
| Pain intensity in last week (NRS %) | 66.1 ± 22.9 |
| Escalated with CGRP-mAbs (n, %) | 10.0 (55.6%) |
| Psychological Status (mean ± SD) | |
| DASS total score (range: 0 to 126) | 21.6.0 ± 14.0 |
| - Depression (range: 0 to 42) | 4.4 ± 5.7 |
| - Anxiety (range: 0 to 42) | 6.0 ± 5.4 |
| - Stress (range: 0 to 42) | 11.2 ± 6.1 |
| Symptoms (median (IQR)) | |
| Pain at time of 1st scan [NRS %] | 40.0 (10.0 to 60.0) |
| Pain at time of 2nd scan [NRS %] | 10.5 (0.0 to 50.0) |
| Time since migraine 1st scan [hours] | 11.0 (0.0 to 48.0) |
| Time since migraine 2nd scan [hours] | 36.0 (4.0 to 168.0) |
| Central Sensitisation Inventory˄ (range: 0 to 100) | 45.0 (36.0 to 50.0) |
| Baseline Clinical status (mean ± SD) | |
| Migraine frequency (days per month) | 16.7 ± 5.1 |
| WHODAS 2.0 (range: 12 to 60) | 24.8 ± 16.1 |
| HIT-6 ǂ (range: 36 to 78) | 65.7 ± 6.6 |
| GABA+ ACC [institutional units, IU] | 4.51 ± 0.38 |
| GABA+ PCG [IU] | 4.93 ± 0.62 |
| Glx ACC [IU] | 13.51 ± 1.25 |
| Glx PCG [IU] | 12.90 ± 1.86 |
Clinical characteristics of participants included in final analysis (n = 18). Data reported as mean ± SD, except where stated non-normally distributed data is reported as Median (IQR). For DASS, CSI, WHODAS, HIT-6 a higher score indicates greater infliction. ˄CSI > 40 indicates central sensitization, ǂHit-6 score > 60 indicate severe impact.