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. 2022 Feb 9;23(1):24. doi: 10.1186/s10194-022-01393-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Change in (A) MMD and (B) WMD in EM patients. Change in MMD represents mean change from baseline during the 4-week period from the first dose (ANCOVA analysis) while change in WMD represents mean change per week during the 4-week period from the first dose (MMRM analysis). An asterisk denotes P < 0.05 and a dagger P < 0.0001 for the comparison with placebo. Abbreviations: ANCOVA, analysis of covariance; LSM, least-squares mean; MMD, monthly migraine days; MMRM, mixed-effects model for repeated measures; WMD, weekly migraine days