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. 2022 Jan 15;23(1):9. doi: 10.1186/s10194-021-01381-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Whole scan connectivity: Significant differences in contralateral dorsolateral prefrontal cortex (dlPFC) whole scan connectivity between controls and migraineurs in the period immediately prior to a migraine headache. Significant clusters are overlaid onto a mean T1-weighted anatomical image. Slice locations in Montreal Neurological Institute space are indicated to the top right of each slice. The dlPFC seed is shown in the lower right inset. Note that connectivity strengths were significantly reduced in a number of brain regions including the orbitofrontal cortex (OFC), putamen, ventroposterior (VP) thalamus, primary motor cortex (M1) and the hypothalamus. Plots of mean (±SEM) beta values (effect sizes) revealed that whole scan connectivity values decreased significantly in migraineurs only during the 24-h period immediately prior to migraine, that is, they were not different between controls and migraineurs during the interictal phase. Beta values indicate the strength of functional connectivity between the dlPFC and respective brain regions