Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 15;23(1):9. doi: 10.1186/s10194-021-01381-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Pain-related connectivity: Significant differences in (A) contralateral dorsolateral prefrontal cortex (dlPFC) and (B) ipsilateral hypothalamus acute pain-evoked changes in connectivity (psychophysiological interaction analysis) between controls and migraineurs in the period immediately prior to a migraine headache. Significant clusters are overlaid onto a mean T1-weighted brainstem template image. Slice locations in Montreal Neurological Institute space are indicated to the top right of each slice. The dlPFC and hypothalamic seeds are shown in the lower right inset. Note that dlPFC pain-related connectivity strengths were significantly reduced in a number of brainstem regions including the dorsomedial pons (dmPons), dorsolateral pons (dlPons), spinal trigeminal nucleus (SpV), and a cluster encompassing the nucleus reticularis dorsalis (SRD)/SpV and rostral ventromedial medulla (RVM). More restricted pain-related hypothalamic connectivity changes occurred in the dlPons, RVM and also in the region of the midbrain periaqueductal gray matter (PAG). Plots of mean (±SEM) beta values (effect sizes) revealed that pain-related changes in connectivity decreased significantly in migraineurs only during the 24-h period immediately prior to migraine, that is they were not different between controls and migraineurs during the interictal phase