Table 3.
Epigenetic functional annotations for selected genome-wide significant and suggestive associations
| rsID | P value | CADD phred | FathmmMKL | Genehancer feature | Genehancer connected gene | Locus |
|---|---|---|---|---|---|---|
| rs11829294 | 2.40e-08 | 3.728 | 0.21 | enhancer | TSPAN9 | TEAD4 (intron) |
| rs10774094 | 5.21e-08 | 0.805 | 0.10 | enhancer | TSPAN9 | TEAD4 (intron) |
| rs16913588 | 2.05e-07 | 7.525 | 0.97 | – | – | intergenic |
| rs58545250 | 2.14e-07 | 9.661 | 0.49 | – | – | RP11-389O22.4 (downstream) |
| rs61114884 | 2.39e-07 | 3.602 | 0.15 | enhancer | TSPAN9 | TEAD4 (intron) |
| rs17031018 | 5.27e-07 | 9.16 | 0.30 | – | – | LRIG2 (intron) |
| rs79946490 | 6.64e-07 | 10.19 | 0.23 | enhancer | ITPR1 | SUMF1 (intron) |
| rs11062457 | 7.44e-07 | 0.362 | 0.13 | enhancer | TSPAN9 | TEAD4 (intron) |
| rs2286647 | 7.46e-07 | 0.16 | 0.07 | enhancer | TSPAN9 | TEAD4 (intron) |
| rs143923810 | 7.73e-07 | 1.518 | 0.04 | enhancer | TSPAN9 | TEAD4 (intron) |
| rs9424366 | 9.86e-07 | 13.82 | 0.13 | enhancer | CLIC4 | NIPAL3 (downstream) |