Table 2.
Amplitude and duration of CSD in different nVNS paradigms
| n | CSD amplitude (mV) | CSD duration (s) | |
|---|---|---|---|
| Amplitude-response | |||
| Sham stimulation | 6 | 21 1.5 |
19 1.7 |
| Low intensity nVNS | 6 | 25 0.8 |
15 0.6 |
| Medium intensity nVNS | 6 | 21 2.5 |
18 1.9 |
| High intensity nVNS | 6 | 19 2.4 |
21 2.7 |
| Dose-response | |||
| Sham stimulation | 8 | 20 0.6 |
23 3.8 |
2 2-min nVNS |
8 | 20 1.3 |
21 0.7 |
3 2-min nVNS |
9 | 21 1.1 |
21 1.3 |
1 6-min nVNS |
8 | 20 0.8 |
21 1.0 |
| Chronic treatment | |||
| Daily nFNS | 6 | 20 0.4 |
20 0.4 |
| Daily nVNS | 8 | 20 0.7 |
21 0.5 |
Data are mean
SEM. P>0.05 in all comparison (student’s t-test)