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. 2022 Feb 8;19:4. doi: 10.1186/s12014-022-09341-5

Table 3.

List of Transcription factors responsible for different biological processes, and the proteins that are identified in the Secretomes of HNSCC cells

Serial. No Most connected biological network Clusters Target genes/Proteins Transcription factors by iRegulon Proteins secreted in cell line HNSCC secretomes
1 Secretory Pathway KLC1, LMAN2, SEC24C, SEC23A, SEC23B, SEC16A, SEC13, TFG, SEC24D, EML4, COPB1, COPB2, GOLGB1, COPA, LMAN1, SEC23IP, SURF4, COPG1 Creb3L1 LMAN2, SEC24C, SEC23A, SEC23B, SEC13, TFG, SEC24D, EML4, COPB1, COPB2, GOLGB1, COPA, LMAN1, COPG1
2 Spliceosomal complex assembly [SF3B1, SNRNP200, SRSF1, SRSF9] ESSRA [SF3B1, SNRNP200, SRSF1, SRSF9]
3 Protein localization to Endosome [PACSIN2, RAB35, VPS35] YY [PACSIN2, VPS35]
4 tRNA aminoacylation for protein translation [AARS1, CARS1, EPRS1, LARS1] ELF2 [AARS1, CARS1, LARS1]
5 Type I interferon pathway/viral process [ADAR, EIF2AK2, IFI16, MX1, OAS2, PLSCR1, STAT1] STAT1 [ADAR, EIF2AK2, STAT1]
6 IRE1-mediate unfolded protein response [DNAJB11, DNAJC3, PDIA5] XBP1 [DNAJB11, DNAJC3]