Table 2.

Serum levels of NGF, BDNF, VEGF and PGE2 biomarkers in study groups

Biomarker	Episodic migraine (n=23)	Chronic migraine (n=36)	Controls (n=30)	P-value¶
	Median (IQR)	Median (IQR)	Median (IQR)
NGF	63.11 (24.56) *, #	75.88 (31.89) *	90.58 (70.25) #	0.009
BDNF	0.49 (0.13) *	0.49 (0.14) #	1.05 (0.96) *, #	<0.001
VEGF	937.41 (230.23)	932.56 (301.35)	646.50 (292.50)	0.046
PGE2	120.71 (19.47)*	134.16 (38.57)	153.50 (55.69)*	0.001

¶: Across group comparison (Kruskal-Wallis); *, #: significant adjusted P-value for pairwise-comparison (Dunn-Bonferroni); NGF: nerve growth factor; BDNF: brain-derived neurotrophic factor; VEGF: vascular endothelial growth factor; PGE2: prostaglandin E2