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. 2022 Jan 12;23(1):5. doi: 10.1186/s10194-021-01371-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Significant differences in resting right V1, V2 and V3 connectivity between controls (n = 71) and migraineurs (n = 32) (random effects, p < 0.05, corrected). A. (left) An overlay of the right V1 seed extracted from the ALFF analysis (pink). Regions in which connectivity strength is significantly greater in migraineurs compared to controls overlaid on a mean T1-weighted anatomical image set. B. (left) An overlay of the right V2 seed (blue). Significant increased connectivity in migraineurs compared to controls, overlaid on a mean T1-weighted anatomical image set. C. (left) An overlay of the right V3 seed (green). Significant increased connectivity in migraineurs compared to controls, overlaid on a mean T1-weighted anatomical image set. D. Overlap (yellow) and non-overlap (green) of significant clusters in V1 and V2 functional connectivity analyses, overlaid on a mean T1-weighted anatomical image set. Location of each axial, coronal and sagittal slice in Montreal Neurological Institute (MNI) space is indicated at the top right of each slice. Slice locations are the same for all three seeds. A1: primary auditory cortex; A2: secondary auditory cortex; M1: primary motor cortex; S1: primary somatosensory cortex; S2: secondary somatosensory cortex; V1: primary visual cortex; V2: secondary visual cortex; V3: third visual complex