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. 2022 Feb 19;27:16. doi: 10.1186/s11658-022-00316-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Bioinformatics analysis of DRG from oxazolone-induced mouse ACD model. A Volcano graph of mRNA expression in DRG of oxazolone (Oxa) group versus control (Con) group. Dots with different colors indicate corresponding expression changes. B Heatmap illustration of the hierarchical clustering of DEmRNAs of oxazolone group versus control group. C, E, and G The top ten most significantly enriched biological processes, molecular functions, and cellular components of upregulated DEmRNAs. D, F, and H The top ten most significantly enriched biological processes, molecular functions, and cellular components of downregulated DEmRNAs. The dotted line indicates q-value of 0.05