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. 2021 Dec 11;22(1):149. doi: 10.1186/s10194-021-01364-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — blockwise comparison of nBR habituation in patients with migraine and controls. R2h is attenuated in migraine and has even a trend towards facilitation in later blocks at V0. After three months of treatment with CGRP mAbs, R2h normalizes and consecutive stimuli are inhibited in all blocks. There remains a significant difference between V3 and controls on the non-stimulated side. * - indicates statistically significant difference between V0 and V3 in migraine. † - indicates statistically significant difference between V0 and controls. # - indicates statistically significant difference between V3 and controls